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. Author manuscript; available in PMC: 2016 May 11.
Published in final edited form as: Sci China Chem. 2014 Nov 15;57(12):1605–1614. doi: 10.1007/s11426-014-5235-3

Figure 2.

Figure 2

(A) Folding topologies of the basket-type Na+-solution (a) and parallel-stranded K+-crystal (b) intramolecular G-quadruplexes formed by human telomeric sequence wtTel22. Red box = anti guanine, Magenta box = syn guanine; (B) the folding topologies (a) and molecular structures (b) of the two equilibrating hybrid-form human telomeric intramolecular G-quadruplexes, hybrid-1 and hybrid-2, in K+ solution; (C) a strand-reorientation model of the interconversion between different forms of human telomeric G-quadruplexes, likely through the two-tetrad and G-triplex form intermediates; (D) the hybrid structures can effectively form packed multimers in human telomeres.