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. Author manuscript; available in PMC: 2016 Sep 10.
Published in final edited form as: Nature. 2016 Mar 10;531(7593):258–262. doi: 10.1038/nature17194

Extended Data Figure 7. Mechanism for TPC gating.

Extended Data Figure 7

A schematic summarizing structural features of TPC1 that suggest mechanisms for voltage-sensing, ion permeation, inhibition by NED19, lumenal Ca2+-inhibition, and cytosolic Ca2+-activation (EF-hand), and phosphoregulation (NTD/CTD). Ca2+ binding (green) and lanthanide (red) binding sites are shown. An ion permeation pathway through the putative selectivity filter, gate, and poly-E and poly-R motifs are summarized. M+ represents a general cation (Na+, K+, Ca2+) and + signs are gating charges.