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. 2016 Apr 12;3(5):314–330. doi: 10.1002/acn3.297

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© 2016 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Results of region‐of‐interest analysis showing that cortical thickness declines significantly with age in the frontal lobes in severely affected PAX6 subjects (bottom row), but not in the mildly affected PAX6 subjects (top row). Parameter assessments and partial correlations, with a Bonferroni‐corrected alpha of 0.004, show that while controls and mildly affected PAX6 subjects had no correlation between left or right frontal lobe thickness and age, respectively (top row), a borderline significant negative correlation was present for severely affected PAX6 subjects (bottom row) (r = −0.857, P < 0.001 and r = −0.755, P = 0.004).