Table 3. . Association of two cis-single nucleotide polymorphisms (rs8102595, rs3826795) with methylation at three sites in HIF3A.
|
Model |
cg27146050 |
cg16672562 |
cg22891070 |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Est. | 95% CI | p-value | Est. | 95% CI | p | Est. | 95% CI | p-value | |
| CpG ˜ rs8102595 |
1.2 |
(0.96–1.5) |
5.7E-19 |
2.9 |
(2.5–3.3) |
1.6E-45 |
3.2 |
(2.8–3.7) |
5.7E-47 |
| CpG ˜ rs3826795 | 0.64 | (0.40–0.87) | 1.1E-07 | 1.6 | (1.2–1.9) | 3.2E-18 | 1.5 | (1.1–1.9) | 3.2E-14 |
Above are results from six different linear regression modelsIn each linear regression model, methylation at each CpG site is regressed against each SNP. Regression coefficients (Est.) and 95% CI reflect changes in % methylation per copy of the effect allele, adjusting for child sex, ethnicity, cell type proportions and interactions between ethnicity and cell type proportions. p-values are two-sided and p-values less than 0.05 are shown in bold. The effect allele of rs8102595 is G and the effect allele of rs3826795 is C.