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. 2016 Jan 27;31:621–629. doi: 10.1007/s11011-016-9792-3

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Reduced white matter volume in T2DM patients compared with lean subjects. a Brain slices showing clusters of reduced white matter volume in the external capsule region in obese T2DM patients compared with lean subjects, as determined with VBM; b Brain slices showing a cluster of reduced white matter volume in the external capsule region in obese compared with lean subjects. This cluster, however, was not statistically significant after FWE-correction for multiple comparisons (P_FWE = 0.380). The color scale reflects the T-value. Right side of the axial slices is the right side of the brain. X, y, z are the Montreal Neurological Institute (MNI) coordinates of the brain in standard space