Table 3.
Uni- and multivariate analyses of predictive markers for overall survival
| Factors | Pts | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|---|
| P | HR | 95%CI | P | HR | 95%CI | ||
| sADC (0% =>) | 15 | 0.001 | 6.8 | 3.0- 15.2 | 0.001 | 6.7 | 2.7- 16.6 |
| wtADC (0%=>) | 16 | 0.657 | 0.9 | 0.4- 1.7 | |||
| CA19-9 (20%<) | 10 | 0.602 | 1.2 | 0.6- 2.7 | |||
| CEA (20%<) | 10 | 0.396 | 1.4 | 0.6- 3.0 | |||
| CRP (20%<) | 12 | 0.002 | 3.3 | 1.6- 7.0 | 0.016 | 2.6 | 1.2- 5.6 |
| LDH (20%<) | 13 | 0.978 | 1.0 | 0.5- 2.0 | |||
| Tumour size (0%<) | 5 | 0.015 | 3.4 | 1.3- 9.0 | 0.545 | 0.7 | 0.2- 2.1 |
CA19-9 = carbohydrate antigen 19-9, sADC = selected area apparent diffusion coefficient, wADC = whole tumour apparent diffusion coefficient, Pts = patients, HR = hazard ratio, CI = confidence interval, CEA = carcinoembryonic antigen, LDH = lactate dehydrogenase, CRP = C-reactive protein