Few studies with validated topical treatment options exist for the management of severe acne. Results of this multicenter, randomized, double-blind, parallel-group clinical trial demonstrate the significantly greater efficacy of adapalene 0.3 %/benzoyl peroxide 2.5 % topical gel compared with vehicle as well as a good safety profile in the treatment of moderate to severe inflammatory non-nodulocystic acne, and particularly high efficacy in subjects with severe inflammatory acne, which increases patients’ treatment options.

A higher concentration of A/BPO will increase treatment options for patients with moderate and severe inflammatory acne.