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. 2016 Apr 14;48(6):2303–2309. doi: 10.3892/ijo.2016.3486

Figure 4.

Figure 4

Effects of PHA-665752 on c-Met phosphorylation and IDO expression in SKOV-3 cells. PHA-665752 inhibited both c-Met phosphorylation and IDO expression of SKOV-3 cells in a concentration-dependent manner (A). Effects of LY294002 on AKT phosphorylation and IDO expression in SKOV-3 cells. LY294002 inhibited both AKT phosphorylation and IDO expression of SKOV-3 cells at the concentration of 10 μM (B). Effects of U0126 on ERK phosphorylation and IDO expression in SKOV-3 cells. While U0126 inhibited ERK phosphorylation of SKOV-3 cells in a concentration-dependent manner, it did not affect their IDO expression (C). Effects of WP1066 on STAT3 phosphorylation and IDO expression in SKOV-3 cells. WP1066 inhibited STAT3 phosphorylation of SKOV-3 cells at the concentration of 10 μM, but did not affect their IDO expression (D).