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. 2016 Apr 1;48(6):2265–2276. doi: 10.3892/ijo.2016.3471

Figure 1.

Figure 1

Combined treatment with PA and TOP inhibitors (Eto and Cpt) synergistically induces apoptosis of NCI-H1299 and A549 cells. (A) Chemical structures of PA (http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=93087), Eto (ref. 5) and Cpt (ref. 10). (B and C) Calculation of the combination index (CI) of PA and Eto/Cpt. The MTT assay was performed to determine the fraction of cells affected on the y-axis. NCI-H1299 cells were co-treated with 0, 7.5, 15, 30 or 60 nM PA and 0, 0.5, 1, 2 or 4 μM Eto or 0, 10, 20, 40 or 80 nM Cpt. A549 cells treated with 0, 7.5, 15, 30 or 60 nM PA and 0, 0.25, 0.5, 1 or 2 μM Eto or 0, 5, 10, 20 or 40 nM Cpt.