Table 2.
A comparison of bcl-2 expression in primary breast carcinomas and paired metastases
| Case | Primary | Metastases | Case characterization | Bcl-2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| ER | PR | HER-2 | ER | PR | HER-2 | Primary | Metastases | ||
| 1 | + | − | − | − | − | − | Luminal A, loss | + | − |
| 2 | + | + | − | + | − | − | Luminal A, loss | + | Variable with increase and decrease in some metastases |
| 3 | + | + | − | − | − | − | Luminal A, loss | + | Variable with decrease in some metastases |
| 4 | + | + | − | + | − | − | Luminal A, loss | + | + |
| 5 | + | + | − | + | − | − | Luminal A, loss | + | − |
| 6 | + | + | − | + | + | − | Luminal A | + | Variable with decrease in some metastases and increase in metastases with ductal morphology and increased PR |
| 7 | + | + | − | + | + | − | Luminal A | Weak + | Variable with increase and decrease in some metastases |
| 8 | + | + | − | + | + | − | Luminal A | + | Variable with decrease in some metastases |
| 9 | + | + | − | + | + | − | Luminal A | + | Variable with decrease in some metastases |
| 10 | + | − | − | + | − | − | Luminal A | + | + |
| 11 | Focal + | Focal + | Focal+ 2+/5.6 |
Focal + | Focal + | − | Luminal B | Weak + | Weak+ |
| 12 | − | − | − | − | − | − | Basal-like carcinoma | − | Variable with increase in some metastases |
| 13 | − | − | − | − | − | − | Basal-like carcinoma | Weak + | − |
| 14 | − | − | − | − | − | − | Basal-like carcinoma | − | − |
| 15 | − | − | − | − | − | − | Basal-like carcinoma | Focal + | Focal + |
| 16 | − | − | − | − | − | − | Basal-like carcinoma | − | − |
| 17 | − | − | 3+ | − | − | 3+ | HER-2 | Focal + | Focal + |
The HER-2 data include the immunohistochemistry result and FISH amplification ratio if available.