Figure 1. EPR detection of S. aureus ROS production.
A. Following inoculation of S. aureus to an initial OD600 of 0.06, cultures were incubated aerobically (flask: volume ratio = 10:1, 250 rpm). Culture samples for EPR analysis were withdrawn at 3 h, 24 h and 72 h of bacterial growth. B. S. aureus culture samples (72 h) were treated with either 400 units of SOD, 20 mM DMTU, or vehicle (wild-type, WT) before addition of the spin probe, CMH. The basal extent of CMH autoxidation in KDD buffer (blue line) was determined as control.