Table 3. Age-, sex- and population stratification-adjusted univariate and bivariate GCTA-derived and LDSC-derived estimates.
| Univariate estimates | n | esta | s.e. |
|---|---|---|---|
| General cognitive function | |||
| Same-sample GCTA | 6273 | 0.29 | 0.06 |
| Independent-samples GCTA | 6985 | 0.31 | 0.05 |
| LDSC | 48 462 | 0.15 | 0.01 |
| BMI | |||
| Same-sample GCTA | 6463 | 0.28 | 0.06 |
| Independent-samples GCTA | 20 806 | 0.22 | 0.02 |
| LDSC | 339 224 | 0.14 | 0.01 |
| Bivariate estimates | N | rG | s.e. |
|---|---|---|---|
| Same-sample GCTA | 6273:6463 | −0.51 | 0.15 |
| Independent-samples GCTA | 6985:20 806 | −0.10 | 0.08 |
| LDSC | 48 462:339 224 | −0.22 | 0.03 |
Abbreviations: BMI, body mass index; GCTA, genome-wide complex trait analysis; LDSC, Linkage Disequilibrium Score Regression; rG, genetic correlation.
a
The proportion of variance in the phenotype explained by common genetic variants.