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. 2016 Feb 9;21(10):1477–1482. doi: 10.1038/mp.2015.205

Table 4. Age- and sex-adjusted polygenic risk score associations with BMI and general cognitive function.

  n Betaa s.e. P-value
General cognitive function polygenic scoreb
 General cognitive function 6273 0.090 0.01 3.3 × 10−13
 BMI 6463 −0.029 0.01 0.020
         
BMI polygenic scoreb
 General cognitive function 6273 −0.065 0.01 1.9 × 10−7
 BMI 6463 0.266 0.01 <2 × 10−16

Abbreviation: BMI, body mass index.

a

The dependent variable and continuous independent variables were standardised in the regression models.

b

Polygenic risk scores were adjusted for age, sex and 14 multi-dimensional scaling components with residuals taken forward as the independent variable of interest.