Table 1.
miRNAs Differentially Expressed Between MDS and Control.
| Study | Cell Source |
Experimental Method |
miRNAs Upregulated Compared to Control |
mRNAs Downregulated Compared to Control |
Experimental Group |
Control |
|---|---|---|---|---|---|---|
| Sokol | BM MNC |
microarray | miR-222, miR-10a | miR-146a, miR-150, Let-7e | Low or INT-1 | Normal |
| Erdogan | BM MNC |
microarray | miR-10b, miR-365, miR-558, miR-636 | miR-23a, miR103, miR- 126, miR-140, miR-150, miR-342, miR-378, miR- 483, miR-632, miR-639 |
Low | Normal |
| Hussein | BM MNC |
qRT-PCR | miR150 | 5q- syndrome | Normal | |
| Pons | BM MNC |
qRT-PCR | miR-17-3p, miR-17-5p, miR-18a, miR-10a, miR-10b, miR-15a, miR-16, miR-222, miR- 155, miR-181a, miR-21, miR-126 |
Multiple Risk Groups |
Normal | |
| Pons | PB | qRT-PCR | miR-17-3p, miR-17-5p, miR-18a, miR-15, miR-21, miR-142-3p |
Multiple Risk Groups |
Normal | |
| Merkerova | CD34+ | microarray | miR-299-3p, miR-299-5p, miR-323-3p, miR-329, miR-370, miR-409-3p, miR-431, miR-432, miR-494, miR-654-5p, miR-665 |
miR-196a*, miR-423-5p, miR-525-5p, miR-507, miR-583, miR-940, miR- 1284, miR-1305 |
Multiple Risk Groups |
Normal |
| Hussein | BM MNC |
Low density qPCR array |
miR-96, miR-339, miR- 182, miR-93, miR-25, miR- 106b, miR-196b, miR-550, miR-148a, miR-29a |
MDS with or without del(7) |
Normal | |
| Starczynowski | BM MNC |
qRT-PCR | miR-145, miR146a | del(5q) | Normal and MDS dip(5q) |
|
| Votavova | CD34+ | qRT-PCR | miR146a | del(5q) | Normal | |
| Votavova | CD34+ | High density qPCR array |
miR-34a, miR-148a, miR-199b, miR-451, miR-486, miR-125a, miR-151, miR-199a, miR-10a, miR-10b, miR-125b, miR-29c, miR-130a, miR-24, miR-126, miR-335, miR-99b |
miR-128b, miR-95, miR- 213, miR-520c |
5q- syndrome | Normal |
| Beck | BM MNC |
Sequencing | miR-376a-2, miR-376a-1, miR-376c, miR- 144, miR-374b*, miR-374a*, miR-126*, miR-17, miR-106a*, miR-10b, miR-10a*, miR-20a, miR-598*, miR-30d, miR-20b* |
RA | Normal | |
| Beck | BM MNC |
Sequencing | miR-127, miR-10b, miR-134, miR-155, miR-125b-2, miR-144, miR-1974**, miR- 1973**, miR-17, miR-20a, miR-139, miR- 30d, miR-216b, miR-19b-2*, miR19b-1 |
RAEB2 | Normal |
BM, bone marrow; MNC, mononuclear cells; PB, peripheral blood; Low, low-risk; INT, intermediate risk; RA, refractory anemia; RAEB, refractory anemia with excess blasts; RCMD, refractory cytopenia with multilineage dysplasia