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. Author manuscript; available in PMC: 2016 May 12.
Published in final edited form as: Chem Res Toxicol. 2015 Jun 11;28(7):1427–1433. doi: 10.1021/acs.chemrestox.5b00097

Table 2.

Kinetic Parameters of Total 3H-DBP Equivalents from Tissues of Mice

plasmaa ovariesa mammarya uterinea livera
Cmax (ng/g) 134.70 ± 11.51c 146.15 ± 14.03 201.25 ± 61.99 121.05 ± 19.84 524.15 ± 63.22
Tmax (h) 10.02 ± 2.10 12.46 ± 2.23 9.78 ± 9.72 17.96 ± 5.07 4.31 ± 2.52
K01 (h−1) 0.33 ± 0.11 0.26 ± 0.08 0.43 ± 0.82 0.15 ± 0.08 1.08 ± 1.00
K10 (h−1) 0.014 ± 0.002 0.013 ± 0.002 0.014 ± 0.009 0.014 ± 0.005 0.015 ± 0.003
T1/2 K01 (h) 2.11 ± 0.73 2.68 ± 0.81 1.60 ± 3.03 4.75 ± 2.51 0.64 ± 0.60
T1/2 K10 (h) 49.05 ± 7.45 51.55 ± 9.20 49.99 ± 30.94 49.90 ± 16.96 45.26 ± 10.65
AUCd 10982.6 ± 1139.9 12780.9 ± 1464.1 16267.2 ± 5920.9 11160.8 ± 2184.0 36392.5 ± 6342.1
Vd (mL) 137.9 ± 16.2 124.52 ± 16.70 94.88 ± 42.10 138.02 ± 36.24 38.40 ± 5.78
Tlag (h) 2.6 × 10−5 ± 0.30 0.41 ± 0.14 1.56 ± 1.22 0.14 ± 0.49 0.31 ± 0.34
ClF 1.95 ± 0.20 1.67 ± 0.19 1.32 ± 0.48 1.92 ± 0.38 0.59 ± 0.10
stomachb intestineb pancreasa spleena kidneya
Cmax (ng/g) 6578.0 ± 678.1 3470.3 ± 644.3 162.21 ± 13.86 127.85 ± 23.85 203.26 ± 17.73
Tmax (h) 2.58 ± 5.26 9.44 ± 4.78 7.69 ± 1.97
K01 (h−1) 1.91 ± 7.10 0.38 ± 0.31 0.50 ± 0.20
K10 (h−1) 0.048 ± 0.008 0.09 ± 0.03 0.014 ± 0.002 0.012 ± 0.004 0.013 ± 0.002
T1/2 K01 (h) 0.36 ± 1.35 1.82 ± 1.49 1.40 ± 0.57
T1/2 K10 (h) 14.53 ± 2.44 7.97 ± 2.80 48.53 ± 7.96 59.07 ± 20.75 53.28 ± 8.40
AUC 137885 ± 21011 42981.1 ± 11664.5 11784.4 ± 1480.0 12171.6 ± 2834.6 17235.5 ± 1954.9
Vd (mL) 3.25 ± 0.34 5.72 ± 0.99 127.15 ± 14.89 149.83 ± 37.64 95.44 ± 10.71
Tlag (h) 2.9 × 10−5 ± 2.4 2.73 × 10−5 ± 0.70 0.15 ± 0.25
ClFe 0.16 ± 0.02 0.50 ± 0.14 1.82 ± 0.23 1.76 ± 0.41 1.24 ± 0.14
bladdera lunga
Cmax (ng/g) 141.30 ± 14.57 202.27 ± 79.89
Tmax (hr) 17.81 ± 3.23 10.31 ± 10.21
K01 (h−1) 0.14 ± 0.05 0.27 ± 0.49
K10 (h−1) 0.015 ± 0.003 0.020 ± 0.018
T1/2 K01 (h) 4.86 ± 1.59 2.54 ± 4.54
T1/2 K10 (h) 45.72 ± 9.13 34.37 ± 30.34
AUC 12166.1 ± 1462.8 12349.5 ± 6545.4
Vd (mL) 116.02 ± 19.18 85.93 ± 55.62
Tlag (h) 0.23 ± 0.27 2.98 × 10−6 ± 1.6
ClF 1.76 ± 0.21 1.73 ± 0.92
a

Data were fitted to the equation C(T) = ((DK01)/(V(K01 – K10)))[e−K10T – e−K01T].

b

Data were fitted to the equation C(T) = (D/V)e−K10T.

c

Results were expressed by the mean ± SD.

d

The unit is h·ng/g.

e

The unit is ng/(h·ng/g).