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. 2016 May 11;11(5):e0155163. doi: 10.1371/journal.pone.0155163

Table 1. Medians and interquartile ranges of histopathological features of steatosis, ballooning, and inflammation as well as NAS of regimen treated C57BL/6, CD-1, and 129Sv mice.

Strain Factor untreated HF EtOH HF + EtOH
7 weeks 12 weeks 14 weeks 16 weeks 5 weeks 7 weeks 9 weeks
C57BL/6 Steatosis 0 (0–0) 1 (0–1) 1 (0.5–1) 1* (1–1) 1 (0–1) 0 (0–0) 1 (0–1) 0 (0–1)
Ballooning 0 (0–0) 2* (1.5–2) 0 (0–0) 0 (0–0) 0 (0–0) 0 (0–0) 0 (0–0.5) 2 (0.5–2)
Inflammation 0 (0–1) 0 (0–0.5) 1 (0.5–1.5) 1 (1–2.5) 2 (0.5–2) 0 (0–0) 1 (0.5–1) 1 (0–2)
NAS 0 (0–1) 3* (2–3) 2 (1.5–2) 2 (2–3.5) 2 (1–3) 0 (0–0) 2 (1–2) 3* (2.5–3)
CD-1 Steatosis 0 (0–0) 0 (0–0.5) 0 (0–0) 1 (0–1) 0 (0–0.5) 0 (0–0.5) 0 (0–0) 0 (0–0)
Ballooning 0 (0–0) 0 (0–0) 0 (0–0) 0 (0–0) 0 (0–0) 0 (0–0) 0 (0–0) 1 (0–1.5)
Inflammation 0 (0–0) 0 (0–1.5) 0 (0–1) 1 (0–1.5) 2 (1–2) 1 (0.5–1.5) 0 (0–1.5) 1 (0.5–2)
NAS 0 (0–0) 1 (0–1.5) 0 (0–1) 1 (0.5–2.5) 2* (1–2.5) 1 (0.5–2) 0 (0–1.5) 2 (0.5–3.5)
129Sv Steatosis 0 (0–0) 1 (1–1) 1 (1–1) 1 (1–1) 1* (1–1.8) 1 (0.5–1) 1 (0.5–1) 1 (0.5–1)
Ballooning 0 (0–0) 0 (0–0) 0 (0–0) 0 (0–0) 0 (0–0) 0 (0–0) 0 (0–0) 0 (0–0)
Inflammation 0 (0–1) 1 (0–1) 3 (0.75–3) 2.(0.5–2) 2.5* (2–3) 0 (0–1) 2 (1.5–2) 2 (2–2.5)
NAS 0 (0–1) 2 (1–2) 4* (1.75–4) 3 (1.5–3) 3.5* (3–4.75) 1 (1–1.5) 3 (2–3) 3* (2.5–3.5)

* differences to untreated group were considered significant for P values of <0.05 by Kruskal-Wallis followed by Dunns test of selected pairs of columns