Table 1. Medians and interquartile ranges of histopathological features of steatosis, ballooning, and inflammation as well as NAS of regimen treated C57BL/6, CD-1, and 129Sv mice.
Strain | Factor | untreated | HF | EtOH | HF + EtOH | ||||
---|---|---|---|---|---|---|---|---|---|
7 weeks | 12 weeks | 14 weeks | 16 weeks | 5 weeks | 7 weeks | 9 weeks | |||
C57BL/6 | Steatosis | 0 (0–0) | 1 (0–1) | 1 (0.5–1) | 1* (1–1) | 1 (0–1) | 0 (0–0) | 1 (0–1) | 0 (0–1) |
Ballooning | 0 (0–0) | 2* (1.5–2) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0.5) | 2 (0.5–2) | |
Inflammation | 0 (0–1) | 0 (0–0.5) | 1 (0.5–1.5) | 1 (1–2.5) | 2 (0.5–2) | 0 (0–0) | 1 (0.5–1) | 1 (0–2) | |
NAS | 0 (0–1) | 3* (2–3) | 2 (1.5–2) | 2 (2–3.5) | 2 (1–3) | 0 (0–0) | 2 (1–2) | 3* (2.5–3) | |
CD-1 | Steatosis | 0 (0–0) | 0 (0–0.5) | 0 (0–0) | 1 (0–1) | 0 (0–0.5) | 0 (0–0.5) | 0 (0–0) | 0 (0–0) |
Ballooning | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 1 (0–1.5) | |
Inflammation | 0 (0–0) | 0 (0–1.5) | 0 (0–1) | 1 (0–1.5) | 2 (1–2) | 1 (0.5–1.5) | 0 (0–1.5) | 1 (0.5–2) | |
NAS | 0 (0–0) | 1 (0–1.5) | 0 (0–1) | 1 (0.5–2.5) | 2* (1–2.5) | 1 (0.5–2) | 0 (0–1.5) | 2 (0.5–3.5) | |
129Sv | Steatosis | 0 (0–0) | 1 (1–1) | 1 (1–1) | 1 (1–1) | 1* (1–1.8) | 1 (0.5–1) | 1 (0.5–1) | 1 (0.5–1) |
Ballooning | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–0) | |
Inflammation | 0 (0–1) | 1 (0–1) | 3 (0.75–3) | 2.(0.5–2) | 2.5* (2–3) | 0 (0–1) | 2 (1.5–2) | 2 (2–2.5) | |
NAS | 0 (0–1) | 2 (1–2) | 4* (1.75–4) | 3 (1.5–3) | 3.5* (3–4.75) | 1 (1–1.5) | 3 (2–3) | 3* (2.5–3.5) |
* differences to untreated group were considered significant for P values of <0.05 by Kruskal-Wallis followed by Dunns test of selected pairs of columns