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. Author manuscript; available in PMC: 2016 Sep 30.
Published in final edited form as: Nature. 2016 Mar 30;532(7597):122–126. doi: 10.1038/nature17178

Extended Data Figure 7. The versican-degrading ADAMTS proteases are regulated by KLF2 and KLF4.

Extended Data Figure 7

a, siRNA knockdown of KLF2 or KLF4 in cultured HUVECs reduces expression of ADAMTS4 measured using qPCR. b, Adenoviral expression of KLF2 drives expression of the versican-degrading proteases ADAMTS1, ADAMTS4 and ADAMTS9 in addition to the known KLF2 target gene eNOS. KLF4 levels are reduced in KLF2-overexpressing HUVECs. Results are shown relative to expression following exposure to control adeno-LacZ virus. c, Adenoviral expression of KLF4 drives expression of ADAMTS4 in addition to the known KLF2/4 target gene eNOS. KLF2 levels are reduced in KLF4-overexpressing HUVECs. Results are shown relative to expression following exposure to control adeno-LacZ virus. N=4–5; ***P<0.001; **P<0.01;*P<0.05. Error bars indicate SEM.