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. Author manuscript; available in PMC: 2016 Sep 30.
Published in final edited form as: Nature. 2016 Mar 30;532(7597):122–126. doi: 10.1038/nature17178

Extended Data Figure 8. The MEK5 inhibitor BIX02189 and the ERK5 inhibitor XMD17–109 reverse the increase in KLF2 and KLF4 expression conferred by loss of KRIT1 in cultured endothelial cells.

Extended Data Figure 8

HUVECs were treated with scrambled (Scr.) or KRIT1-targeted siRNAs with and without BIX02189 (10 μM) and XMD17-109 (1 μM) for 24 hours and the levels of KLF2 and KLF4 mRNA measured using qPCR. *** indicates P<0.001; ** indicates P<0.01. N=3. Error bars indicate SEM.