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. Author manuscript; available in PMC: 2016 Sep 30.
Published in final edited form as: Nature. 2016 Mar 30;532(7597):122–126. doi: 10.1038/nature17178

Extended Data Figure 3. Hes1 expression rises after primary CCM lesion formation in Krit1ECKO hindbrain endothelial cells and is reversed by Map3k3 haploinsufficiency.

Extended Data Figure 3

a, qPCR analysis of Notch target genes in endothelial cells freshly harvested from the hindbrain of P6 or P11 Krit1ECKO animals compared with control, tamoxifen-treated littermates. ** indicates P<0.01. N=4. Error bars indicate SEM. b, qPCR analysis of gene expression in endothelial cells freshly harvested from the cerebellum of P11 Krit1fl/fl and Krit1ECKO animals with and without endothelial loss of one Map3k3 allele. ** indicates P<0.01. N=4. Error bars indicate SEM.