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. Author manuscript; available in PMC: 2016 May 12.
Published in final edited form as: Cell Rep. 2015 Nov 5;13(7):1336–1342. doi: 10.1016/j.celrep.2015.10.015

Figure 2.

Figure 2

NO producing interneurons can induce NO-LTD. (A) Simplified diagram depicting the experimental design used to optogenetically probe PLTSI involvement in NO-LTD. (B) Full field LED activation of PLTSIs for 5 minutes at 15 Hz induced NO-LTD at corticostriatal synapses in SPNs synaptically coupled to PLTSIs. Example traces shown to the right. (C) LTD was blocked by continuous bath application of the nNOS inhibitor L-NAME (100 μM) or inclusion of Rp8Br (3 μM) in the patch pipette (control: n=5; L-NAME: n=6; Rp8Br: n=5). Example EPSCs are shown at right. (D) Summary data for NO-LTD induced by PLTSI activation. SPNs not coupled to PLTSIs showed no response to the PLTSI stimulation paradigm (n=4). **p<0.01 Mann-Whitney nonparametric test. Scale bars: (B), (C) 20 pA, 10 ms.