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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Exp Hematol. 2016 Mar 11;44(6):458–465. doi: 10.1016/j.exphem.2016.03.001

Figure 2.

Figure 2

Drug combinations activate the DNA-damage response and induce apoptosis in J45.01 (A) and U937 (B). Cells were exposed to Clad, Gem, Bu and SAHA alone, or in combination, for 48 h and changes in the level and modification of proteins involved in the ATM pathway were analyzed by Western blotting. Clad: cladribine; Gem: gemcitabine; Bu: busulfan; SAHA: suberoylanilide hydroxamic acid