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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Exp Hematol. 2016 Mar 11;44(6):458–465. doi: 10.1016/j.exphem.2016.03.001

Figure 6.

Figure 6

Pre-exposure of lymphoma cells to SAHA enhances toxicity of [Clad+Gem+Bu] and [Clad+Gem+Bu+SAHA] combinations. Cells were exposed to SAHA for 4 h, washed, then exposed to [Clad+Gem+Bu] or [Clad+Gem+Bu+SAHA] combination using the indicated drug concentrations (A). Changes in the level of proteins involved in DNA-damage response and apoptosis were analyzed by Western blotting (B). Cell proliferation was determined by the MTT assay (C and D). Clad: cladribine; Gem: gemcitabine; Bu: busulfan; SAHA: suberoylanilide hydroxamic acid; Casp: caspase