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. 2015 Sep;7(6):921–935. doi: 10.2217/epi.15.47

Figure 3. . Histone methylation at enhancers.

Figure 3. 

Enhancers were grouped based on whether they had H3K4me3 or H3K27me3 change in systemic lupus erythematosus (SLE) and the change direction. The averages of four histone modifications and CTCF in CD14+ monocytes were compared across regions exhibiting changes in H3K4me3 or H3K27me3 in SLE. Enhancers generally had higher H3K4me1 and lower H3K4me3 and CTCF than other DHS regions (gray bars). Enhancers with increased H3K4me3 in SLE (red) had the highest level of H3K27ac, a mark of active enhancers.

CTCF: CCCTC-binding factor; DHS: DNase hypersensitivity site.