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. 2015 Sep;7(6):921–935. doi: 10.2217/epi.15.47

Figure 4. . Position weight matrice analysis of promoters and enhancers impacted by systemic lupus erythematosus.

Figure 4. 

(A) Enrichment of selected position weight matrices (PWMs) around subsets of promoters and enhancers having significant H3K4me3 change in systemic lupus erythematosus (SLE). The relative enrichment was computed using the promoters or enhancers without significant H3K4me3 change as background. Most of the PWMs were enriched (red) around promoters and enhancers with decreased H3K4me3 while some PWMs were less likely to be found (pale yellow) around promoters and enhancers with increased H3K4me3. (B) Differential H3K4me3 in SLE was associated with differential IRF1 binding at nearby sites. While IRF1 binding was increased around monocyte promoters in general, there was a positive correlation between IRF1 binding change and H3K4me3 change in SLE. At enhancers, increased IRF1 binding was associated with H3K4me3 change in either direction.