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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Int J Toxicol. 2016 Apr 21;35(3):344–357. doi: 10.1177/1091581816638086

Table 5.

MLD and Protective Ratios for Treatment Groups

Challenge Compound Therapy n MLD (mg/kg) 95% Confidence Interval Probit Slope PR1 p value1
Aldicarb Saline/Saline 36 0.86 (0.74, 1.51) 18 N/A N/A
Atropine/Saline 30 2.82 (2.43, 3.46) 15 3.30 <0.0001
2-PAM/Saline 30 1.15 (0.96, 1.39) 10 1.34 0.003
Atropine/2-PAM 30 2.31 (1.45, 5.74) 3.0 2.70 <0.0001
Methomyl Saline/Saline 36 8.06 (7.07, 8.97) 18 N/A N/A
Atropine/Saline 30 15.20 (9.49, 23.94) 4.0 1.89 0.0003
2-PAM/Saline 30 9.22 (6.68, 10.79) 12 1.14 0.0683
Atropine/2-PAM 30 22.95 (17.62, 27.87) 13 2.85 <0.0001
1

Protective ratio, the shift in the MLD between treatment groups, compared to Saline/Saline treated animals