Table 2.
SFPQ-TFE3 Cases
| Case | Age/Sex | Tumor Type | Size and Stage | Immunohistochemistry | Comment | Other publication |
|---|---|---|---|---|---|---|
| 1 | 36/F | RCC | 7.8cm, pT2NXMX, II | PAX8+; Cathepsin K− | Sarcomatoid, recurred in retroperitoneum after 3 years | Reference 11, Case 2 |
| 2 | 63/F | RCC | 3.5cm, pT1NX, I (partial nephrectomy) | PAX8, Racemase +; Cathepsin K, Cytokeratin 7, CA-IX− | ||
| 3 | 32/F | RCC | 4.7cm, pT1NX, I (partial nephrectomy) | PAX8, Racemase+; Cathepsin K, Cytokeratin 7, CA-IX, EMA− | Ipsilateral partial nephrectomy 4 years later for clear cell RCC | |
| 4 | 24/F | RCC | 3cm, pT1NX, I (partial nephrectomy) | PAX8, CD10, RCC marker, Racemase+; CA-IX rare cells +; Cathepsin K, CK7−, | ||
| 5 | 48/F | RCC | 4cm, pT1NX, I | PAX8+; Cathepsin K, Vimentin, CA-IX− | ||
| 6 | 51/F | RCC | 7.4cm, pT2NX, II (partial nephrectomy) | PAX8, CD10+; Cathepsin K, Cytokeratin AE1/3 focal+; HMB45, Melan A− | ||
| 7 | 19/M | RCC | 1.6cm, pT1NX, I (partial nephrectomy) | PAX8+; Cathepsin K− | ||
| 8 | 35/F | Xp11 PEComa | Kidney, pT3aN1, clinical stage IV | Cathepsin K, HMB45+; PAX8−, Cytokeratin− | Multiple copies of fusion | Reference 11, Case 3 |
| 9 | 4/F | Xp11 PEComa | 1.3cm, Renal sinus | Cathepsin K+, HMB45+; PAX8, Cytokeratin, S100 Melan A, EMA, RCC marker− | ||
| 10 | 27/F | Xp11 PEComa | Bladder | Cathepsin K, HMB45+; PAX8, Melan A, Desmin, Actin, S100− | Developed pelvic lymph node metastases at 6 months | Reference 27 |
| 11 | 9/M | Xp11 PEComa | 7cm, Kidney, pT3N1 clinical stage IV | Cathepsin K, HMB45, Melan A+; PAX8, Cytokeratin, Desmin, S100 protein, CD34− | ||
| 12 | 46/F | Xp11 PEComa | 6.5cm, Thigh | Cathepsin K+; PAX8− | SFPQ exon 9-TFE3 exon 6 fusion | Reference 20, Case 4. |
| 13 | 21/F | Xp11 PEComa | 6cm, Pelvis | Cathepsin K+; HMB45 focal+; PAX8, Melan A, Actin, Desmin, Cytokeratin− | ||
| 14 | 9/F | Xp11 PEComa | 5cm, Uterus. Lymph node metastases at diagnosis. | Cathepsin K, HMB45+; PAX8, Melan A, S100, Desmin, Actin− | SFPQ exon 9- TFE3 exon 6 fusion | Reference 20, Case 2. |
| 15 | 11/M | Melanotic Xp11 Renal Cancer | 21cm, pT3N1M1, IV | Cathepsin K, Melan A, HMB45+; PAX8, Cytokeratin, RCC marker, Actin, Desmin, S100− | Reference 25, case 1 | |
| 16 | 34/F | Melanotic Xp11 Renal Cancer | 4.8cm, pT1NXMX, I (partial nephrectomy) | Cathepsin K, HMB45+; PAX8, CD10, Cytokeratin, EMA, Desmin,− | SFPQ exon 9- TFE3 exon 6 fusion | Reference 28. |
| 17 | 30/F | Melanotic Xp11 Renal Cancer | 12.5cm, pT3NX (clinically stage IV, thrombus in inferior vena cava and pulmonary artery) | Cathepsin K, HMB45, Melan A+; PAX8, Cytokeratin, CD10, Desmin, S100− | SFPQ exon 9- TFE3 exon 6 fusion | Reference 29 |
| 18 | 34/M | Melanotic Xp11 Renal Cancer | 9.7cm pT2NX, II | Cathepsin K, HMB45+; Melan A focal+; PAX8, Cytokeratin, S100− | SFPQ exon 9- TFE3 exon 6 fusion |