Table 2.
Characteristics of the patient cohorts. Data are presented as mean (range). CHLA, Children’s Hospital Los Angeles; Cave, average concentration over 96 hours.
| Cohort | Model Building | Validation 1 | Validation 2 | BestDose |
|---|---|---|---|---|
| Source | CHLA | Lyon | CHLA | CHLA |
| Number | 53 | 105 | 11 | 20 |
| Age (years) | 7.8 (0.2 – 19.0) | 5.6 (0.1 – 21) | 5.8 (0.5 – 14.2) | 10.2 (0.25 – 18) |
| Weight (kg) | 26.5 (5.6 – 78.0) | 20.3 (3.4 – 59.6) | 22.7 (5.2 – 53.4) | 46.4 (5.2 – 110.9) |
| All Doses (mg/kg) | 1.1 (0.7 – 1.8) | 1.2 (0.6 – 5.2) | 1.2 (0.9 – 1.5) | 0.83 (0.5 – 1.3) |
| Samples/patient | 16.7 (6 – 26) | 3.3 (1 – 13) | 15.9 (8 – 26) | 25.2 (17 – 26) |
| Cave(ng/mL) | 750 (390 – 1190) | 750 (390 – 1860) | 780 (550 – 950) | 714 (564 – 914) |