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A-D, High-grade astrocytoma (A–F) had increased cellularity, nuclear atypia, necrosis (B–C, red arrow), florid microvascular proliferation (D, black arrow), and brisk mitotic activity (E, blue arrow). Tumor cells expressed glial fibrillary acidic protein (G) and demonstrated a high proliferative index (H–Ki-67/MIB-1).
