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. Author manuscript; available in PMC: 2017 May 10.
Published in final edited form as: Cell Metab. 2016 Apr 28;23(5):909–920. doi: 10.1016/j.cmet.2016.04.002

Figure 4. Age-dependent islet genes are enriched for genes linked to diabetes and related metabolic traits.

Figure 4

(A) Box plots displaying normalized transcript counts of TFs whose expression changes significantly with age (except for MAFB) in human α- or β-cells, (n=5 juvenile, n=5 adult). (B) RNA-Seq profiles of α- and β-cells from juvenile and adult samples highlighting the PCSK1 and lncPCSK1-1 locus. (C) Matrix indicating the overlap of age-dependent genes and GWAS genes linked to diabetes and associated metabolic traits (* Chi-square test with Yates' correction).