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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Nov 11;1863(7 Pt B):1839–1847. doi: 10.1016/j.bbamcr.2015.11.004

Figure 1.

Figure 1

Schematic illustration of BIN1-regulated cardiac t-tubule function. Top: cartoon of mammalian adult ventricular cardiomyocytes, which are rod-shaped striated muscle cells with t-tubule invagination occurring periodically at the Z-lines of myofilament. Bottom: The “banana” molecule BIN1 regulates cardiac t-tubule function through: (1) facilitating microtubule-dependent targeted delivery of LTCCs to t-tubules; (2) clustering LTCCs at the t-tubule surface; (3) creating a slow diffusion zone within t-tubule lumen for extracellular ions; (4) organizing microdomains critical for dyad formation and functions.