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. Author manuscript; available in PMC: 2017 Jun 20.
Published in final edited form as: Neurosci Lett. 2015 Nov 11;625:34–39. doi: 10.1016/j.neulet.2015.10.060

Fig 1.

Fig 1

Summary of environmental factors that can affect epigenetic changes in the brain and how these lead to altered behavior that might be inherited. Mutant huntingtin protein (mHtt) is known to alter several epigenetic mechanisms, including histone acetylation (Histone-Ac), histone methylation (Histone-Me) and DNA methylation (DNA-Me). These lead to epigenetic changes in the brain and ensuing disease symptoms. Many environmental factors, such as those listed, are known to improve or worsen disease symptoms in HD mouse models and humans. These factors can also influence epigenetic factors, such as DNA methylation, leading to persistent changes and could have detrimental or beneficial effects in offspring.