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. 2015 Nov 3;18(6):797–806. doi: 10.1093/neuonc/nov272

Fig. 1.

Fig. 1.

IR induces expression of CSF-1R ligands in GBM tumors. Subcutaneous U251-luc (A and D) and GBM12 (B and E) tumors were irradiated with a single dose of 12 Gy and assayed for CSF-1 and IL-34 expression at different time points by quantitative (q)PCR (Untr = untreated controls). (C) Intracranial U251-luc tumors irradiated with 12 Gy were assayed for CSF-1 and IL-34 expression by western blot at 7 d after IR. (F) U251-luc cells growing in culture were irradiated with 5 Gy and analyzed by qPCR 48 h later. CSF-1 and IL-34 expression were normalized to β-actin expression in each experiment. Error bars represent mean ± SEM for n = 5–6 mice or 4 culture flasks per group. ***P < .001 and **P < .01; Student's t-test.