Fig. 4.

Effect of marizomib regiments on the proteasome activity of prefrontal cortex in cynomolgus monkeys. (A) The chymotrypsin-like, C-L and T-L activities were assessed in control monkey prefrontal cortex in vivo, and all 3 proteasome activities were present at levels well distinguished from baseline. (B) Marizomib administered orally resulted in a differential inhibition of proteasome activities in monkey prefrontal cortex. The degree of inhibition observed was very similar for the twice-weekly and once-weekly dosing schedules.