Table 3.
Association of polymorphisms within the genes encoding Toll-like receptors (TLRs) and Triggering receptor expressed on myeloid cells-1 (TREM-1) with coronary atherosclerosis regarding SYNTAX score (after the adjustments by age and gender).
| Polymorphism | Inheritance model | Genotype | SYNTAX score 0–22 | SYNTAX score > 22 | OR (95% CI) | P value | HWE |
|---|---|---|---|---|---|---|---|
| TLR1 gene | |||||||
| rs5743551 | Codominant | T/T | 114 (63.3%) | 76 (69.1%) | 1.00 | 0.62 | 0.85 |
| C/T | 60 (33.3%) | 31 (28.2%) | 0.78 (0.46–1.32) | ||||
| C/C | 6 (3.3%) | 3 (2.7%) | 0.75 (0.18–3.10) | ||||
| Dominant | T/T | 114 (63.3%) | 76 (69.1%) | 1.00 | 0.33 | ||
| C/T-C/C | 66 (36.7%) | 34 (30.9%) | 0.78 (0.47–1.29) | ||||
| Recessive | T/T-C/T | 174 (96.7%) | 107 (97.3%) | 1.00 | 0.77 | ||
| C/C | 6 (3.3%) | 3 (2.7%) | 0.81 (0.20–3.32) | ||||
| Overdominant | T/T-C/C | 120 (66.7%) | 79 (71.8%) | 1.00 | 0.37 | ||
| C/T | 60 (33.3%) | 31 (28.2%) | 0.79 (0.47–1.33) | ||||
| Log-additive | – | – | – | 0.81 (0.52–1.26) | 0.34 | ||
| rs5743611 | Codominant | C/C | 107 (59.4%) | 65 (58.6%) | 1.00 | 0.99 | 0.87 |
| C/G | 63 (35%) | 40 (36%) | 1.03 (0.62–1.71) | ||||
| G/G | 10 (5.6%) | 6 (5.4%) | 0.97 (0.33–2.79) | ||||
| Dominant | C/C | 107 (59.4%) | 65 (58.6%) | 1.00 | 0.92 | ||
| C/G-G/G | 73 (40.6%) | 46 (41.4%) | 1.02 (0.63–1.66) | ||||
| Recessive | C/C-C/G | 170 (94.4%) | 105 (94.6%) | 1.00 | 0.93 | ||
| G/G | 10 (5.6%) | 6 (5.4%) | 0.95 (0.34–2.71) | ||||
| Overdominant | C/C-G/G | 117 (65%) | 71 (64%) | 1.00 | 0.89 | ||
| C/G | 63 (35%) | 40 (36%) | 1.04 (0.63–1.70) | ||||
| Log-additive | – | – | – | 1.01 (0.68–1.50) | 0.96 | ||
| TLR2 gene | |||||||
| rs5743708 | — | G/G | 164 (91.1%) | 104 (93.7%) | 1.00 | 0.43 | 0.99 |
| A/G | 16 (8.9%) | 7 (6.3%) | 0.69 (0.28–1.74) | ||||
| rs3804099 | Codominant | T/T | 82 (45.6%) | 41 (36.9%) | 1.00 | 0.066 | 0.32 |
| C/T | 74 (41.1%) | 44 (39.6%) | 1.19 (0.70–2.03) | ||||
| C/C | 24 (13.3%) | 26 (23.4%) | 2.21 (1.13–4.35) | ||||
| Dominant | T/T | 82 (45.6%) | 41 (36.9%) | 1.00 | 0.14 | ||
| C/T-C/C | 98 (54.4%) | 70 (63.1%) | 1.44 (0.88–2.34) | ||||
| Recessive | T/T-C/T | 156 (86.7%) | 85 (76.6%) | 1.00 | 0.025 | ||
| C/C | 24 (13.3%) | 26 (23.4%) | 2.03 (1.09–3.77) | ||||
| Overdominant | T/T-C/C | 106 (58.9%) | 67 (60.4%) | 1.00 | 0.79 | ||
| C/T | 74 (41.1%) | 44 (39.6%) | 0.94 (0.58–1.52) | ||||
| Log-additive | – | – | – | 1.43 (1.03–1.99) | 0.031 | ||
| TLR4 gene | |||||||
| rs4986790 | Codominant | A/A | 155 (86.1%) | 90 (81.1%) | 1.00 | 0.46 | 0.99 |
| A/G | 24 (13.3%) | 20 (18%) | 1.49 (0.77–2.87) | ||||
| G/G | 1 (0.6%) | 1 (0.9%) | 1.78 (0.10–30.27) | ||||
| Dominant | A/A | 155 (86.1%) | 90 (81.1%) | 1.00 | 0.22 | ||
| A/G-G/G | 25 (13.9%) | 21 (18.9%) | 1.50 (0.79–2.85) | ||||
| Recessive | A/A-A/G | 179 (99.4%) | 110 (99.1%) | 1.00 | 0.71 | ||
| G/G | 1 (0.6%) | 1 (0.9%) | 1.71 (0.10–29.03) | ||||
| Overdominant | A/A-G/G | 156 (86.7%) | 91 (82%) | 1.00 | 0.24 | ||
| A/G | 24 (13.3%) | 20 (18%) | 1.48 (0.77–2.86) | ||||
| Log-additive | – | – | – | 1.46 (0.80–2.67) | 0.22 | ||
| rs4986791 | Codominant | C/C | 154 (85.6%) | 89 (80.2%) | 1.00 | 0.43 | 0.99 |
| C/T | 25 (13.9%) | 21 (18.9%) | 1.51 (0.79–2.87) | ||||
| T/T | 1 (0.6%) | 1 (0.9%) | 1.78 (0.10–30.30) | ||||
| Dominant | C/C | 154 (85.6%) | 89 (80.2%) | 1.00 | 0.2 | ||
| C/T-T/T | 26 (14.4%) | 22 (19.8%) | 1.52 (0.81–2.86) | ||||
| Recessive | C/C-C/T | 179 (99.4%) | 110 (99.1%) | 1.00 | 0.71 | ||
| T/T | 1 (0.6%) | 1 (0.9%) | 1.71 (0.10–29.03) | ||||
| Overdominant | C/C-T/T | 155 (86.1%) | 90 (81.1%) | 1.00 | 0.22 | ||
| C/T | 25 (13.9%) | 21 (18.9%) | 1.50 (0.79–2.86) | ||||
| Log-additive | – | – | – | 1.48 (0.82–2.67) | 0.2 | ||
| TLR6 gene | |||||||
| rs3775073 | Codominant | T/T | 58 (32.2%) | 33 (29.7%) | 1.00 | 0.83 | 0.91 |
| T/C | 88 (48.9%) | 54 (48.6%) | 1.06 (0.62–1.84)– | ||||
| C/C | 34 (18.9%) | 24 (21.6%) | 1.24 (0.63–2.43) | ||||
| Dominant | T/T | 58 (32.2%) | 33 (29.7%) | 1.00 | 0.69 | ||
| T/C-C/C | 122 (67.8%) | 78 (70.3%) | 1.11 (0.66–1.86) | ||||
| Recessive | T/T-T/C | 146 (81.1%) | 87 (78.4%) | 1.00 | 0.56 | ||
| C/C | 34 (18.9%) | 24 (21.6%) | 1.19 (0.66–2.14) | ||||
| Overdominant | T/T-C/C | 92 (51.1%) | 57 (51.4%) | 1.00 | 0.93 | ||
| T/C | 88 (48.9%) | 54 (48.6%) | 0.98 (0.61–1.57) | ||||
| Log-additive | – | – | – | 1.11 (0.79–1.55) | 0.55 | ||
| rs5743810 | Codominant | G/G | 78 (43.3%) | 45 (40.5%) | 1.00 | 0.8 | 0.52 |
| A/G | 79 (43.9%) | 49 (44.1%) | 1.06 (0.64–1.78) | ||||
| A/A | 23 (12.8%) | 17 (15.3%) | 1.29 (0.62–2.66) | ||||
| Dominant | G/G | 78 (43.3%) | 45 (40.5%) | 1.00 | 0.66 | ||
| A/G-A/A | 102 (56.7%) | 66 (59.5%) | 1.11 (0.69–1.80) | ||||
| Recessive | G/G-A/G | 157 (87.2%) | 94 (84.7%) | 1.00 | 0.53 | ||
| A/A | 23 (12.8%) | 17 (15.3%) | 1.25 (0.63–2.46) | ||||
| Overdominant | G/G-A/A | 101 (56.1%) | 62 (55.9%) | 1.00 | 0.99 | ||
| A/G | 79 (43.9%) | 49 (44.1%) | 1.00 (0.63–1.61) | ||||
| Log-additive | – | – | – | 1.12 (0.79–1.57) | 0.53 | ||
| TREM-1 gene | |||||||
| rs2234246 | Codominant | C/C | 61 (33.9%) | 49 (44.1%) | 1.00 | 0.18 | 0.14 |
| C/T | 86 (47.8%) | 42 (37.8%) | 0.61 (0.36–1.03) | ||||
| T/T | 33 (18.3%) | 20 (18%) | 0.75 (0.38–1.47) | ||||
| Dominant | C/C | 61 (33.9%) | 49 (44.1%) | 1.00 | 0.082 | ||
| C/T-T/T | 119 (66.1%) | 62 (55.9%) | 0.65 (0.40–1.06) | ||||
| Recessive | C/C-C/T | 147 (81.7%) | 91 (82%) | 1.00 | 0.93 | ||
| T/T | 33 (18.3%) | 20 (18%) | 0.97 (0.53–1.80) | ||||
| Overdominant | C/C-T/T | 94 (52.2%) | 69 (62.2%) | 1.00 | 0.1 | ||
| C/T | 86 (47.8%) | 42 (37.8%) | 0.67 (0.41–1.08) | ||||
| Log-additive | – | – | – | 0.81 (0.58–1.13) | 0.22 | ||
| rs4711668 | Codominant | C/C | 60 (33.5%) | 39 (35.1%) | 1.00 | 0.14 | 0.23 |
| T/C | 80 (44.7%) | 38 (34.2%) | 0.75 (0.43–1.31) | ||||
| T/T | 39 (21.8%) | 34 (30.6%) | 1.37 (0.74–2.53) | ||||
| Dominant | C/C | 60 (33.5%) | 39 (35.1%) | 1.00 | 0.85 | ||
| T/C-T/T | 119 (66.5%) | 72 (64.9%) | 0.95 (0.58–1.57) | ||||
| Recessive | C/C-T/C | 140 (78.2%) | 77 (69.4%) | 1.00 | 0.09 | ||
| T/T | 39 (21.8%) | 34 (30.6%) | 1.60 (0.93–2.74) | ||||
| Overdominant | C/C-T/T | 99 (55.3%) | 73 (65.8%) | 1.00 | 0.088 | ||
| T/C | 80 (44.7%) | 38 (34.2%) | 0.65 (0.40–1.07) | ||||
| Log-additive | – | – | – | 1.14 (0.84–1.56) | 0.39 | ||
| rs3804277 | Codominant | C/C | 66 (36.7%) | 49 (44.1%) | 1.00 | 0.36 | 0.11 |
| C/T | 83 (46.1%) | 42 (37.8%) | 0.68 (0.40–1.15) | ||||
| T/T | 31 (17.2%) | 20 (18%) | 0.86 (0.44–1.69) | ||||
| Dominant | C/C | 66 (36.7%) | 49 (44.1%) | 1.00 | 0.2 | ||
| C/T-T/T | 114 (63.3%) | 62 (55.9%) | 0.73 (0.45–1.18) | ||||
| Recessive | C/C-C/T | 149 (82.8%) | 91 (82%) | 1.00 | 0.89 | ||
| T/T | 31 (17.2%) | 20 (18%) | 1.05 (0.56–1.95) | ||||
| Overdominant | C/C-T/T | 97 (53.9%) | 69 (62.2%) | 1.00 | 0.17 | ||
| C/T | 83 (46.1%) | 42 (37.8%) | 0.71 (0.44–1.16) | ||||
| Log-additive | – | – | – | 0.88 (0.63–1.22) | 0.43 | ||
| rs2234237 | Codominant | T/T | 138 (76.7%) | 86 (77.5%) | 1.00 | 0.9 | 0.19 |
| A/T | 37 (20.6%) | 21 (18.9%) | 0.91 (0.50–1.66) | ||||
| A/A | 5 (2.8%) | 4 (3.6%) | 1.23 (0.32–4.74) | ||||
| Dominant | T/T | 138 (76.7%) | 86 (77.5%) | 1.00 | 0.85 | ||
| A/T-A/A | 42 (23.3%) | 25 (22.5%) | 0.95 (0.54–1.67) | ||||
| Recessive | T/T-A/T | 175 (97.2%) | 107 (96.4%) | 1.00 | 0.74 | ||
| A/A | 5 (2.8%) | 4 (3.6%) | 1.25 (0.33–4.81) | ||||
| Overdominant | T/T-A/A | 143 (79.4%) | 90 (81.1%) | 1.00 | 0.73 | ||
| A/T | 37 (20.6%) | 21 (18.9%) | 0.90 (0.50–1.64) | ||||
| Log-additive | – | – | – | 0.99 (0.62–1.58) | 0.97 | ||
| rs6910730 | Codominant | A/A | 140 (77.8%) | 87 (78.4%) | 1.00 | 0.75 | 0.31 |
| A/G | 36 (20%) | 20 (18%) | 0.89 (0.48–1.63) | ||||
| G/G | 4 (2.2%) | 4 (3.6%) | 1.55 (0.38–6.40) | ||||
| Dominant | A/A | 140 (77.8%) | 87 (78.4%) | 1.00 | 0.87 | ||
| A/G-G/G | 40 (22.2%) | 24 (21.6%) | 0.95 (0.54–1.69) | ||||
| Recessive | A/A-A/G | 176 (97.8%) | 107 (96.4%) | 1.00 | 0.52 | ||
| G/G | 4 (2.2%) | 4 (3.6%) | 1.59 (0.39–6.53) | ||||
| Overdominant | A/A-G/G | 144 (80%) | 91 (82%) | 1.00 | 0.66 | ||
| A/G | 36 (20%) | 20 (18%) | 0.87 (0.47–1.60) | ||||
| Log-additive | – | – | – | 1.02 (0.63–1.65) | 0.94 | ||
| rs1817537 | Codominant | C/C | 66 (36.7%) | 49 (44.1%) | 1.00 | 0.36 | 0.64 |
| C/G | 83 (46.1%) | 42 (37.8%) | 0.68 (0.40–1.15) | ||||
| G/G | 31 (17.2%) | 20 (18%) | 0.86 (0.44–1.69) | ||||
| Dominant | C/C | 66 (36.7%) | 49 (44.1%) | 1.00 | 0.2 | ||
| C/G-G/G | 114 (63.3%) | 62 (55.9%) | 0.73 (0.45–1.18) | ||||
| Recessive | C/C-C/G | 149 (82.8%) | 91 (82%) | 1.00 | 0.89 | ||
| G/G | 31 (17.2%) | 20 (18%) | 1.05 (0.56–1.95) | ||||
| Overdominant | C/C-G/G | 97 (53.9%) | 69 (62.2%) | 1.00 | 0.17 | ||
| C/G | 83 (46.1%) | 42 (37.8%) | 0.71 (0.44–1.16) | ||||
| Log-additive | – | – | – | 0.88 (0.63–1.22) | 0.43 | ||
| rs9471535 | Codominant | T/T | 137 (76.5%) | 84 (76.4%) | 1.00 | 0.94 | 0.19 |
| C/T | 37 (20.7%) | 22 (20%) | 0.97 (0.53–1.75) | ||||
| C/C | 5 (2.8%) | 4 (3.6%) | 1.24 (0.32–4.77) | ||||
| Dominant | T/T | 137 (76.5%) | 84 (76.4%) | 1.00 | 0.99 | ||
| C/T-C/C | 42 (23.5%) | 26 (23.6%) | 1.00 (0.57–1.75) | ||||
| Recessive | T/T-C/T | 174 (97.2%) | 106 (96.4%) | 1.00 | 0.75 | ||
| C/C | 5 (2.8%) | 4 (3.6%) | 1.25 (0.33–4.78) | ||||
| Overdominant | T/T-C/C | 142 (79.3%) | 88 (80%) | 1.00 | 0.89 | ||
| C/T | 37 (20.7%) | 22 (20%) | 0.96 (0.53–1.73) | ||||
| Log-additive | – | – | – | 1.03 (0.64–1.64) | 0.91 | ||
| rs7768162 | Codominant | G/G | 63 (35.2%) | 41 (37.3%) | 1.00 | 0.21 | 0.63 |
| A/G | 90 (50.3%) | 45 (40.9%) | 0.79 (0.46–1.35) | ||||
| A/A | 26 (14.5%) | 24 (21.8%) | 1.42 (0.72–2.81) | ||||
| Dominant | G/G | 63 (35.2%) | 41 (37.3%) | 1.00 | 0.8 | ||
| A/G-A/A | 116 (64.8%) | 69 (62.7%) | 0.94 (0.57–1.54) | ||||
| Recessive | G/G-A/G | 153 (85.5%) | 86 (78.2%) | 1.00 | 0.13 | ||
| A/A | 26 (14.5%) | 24 (21.8%) | 1.62 (0.88–3.01) | ||||
| Overdominant | G/G-A/A | 89 (49.7%) | 65 (59.1%) | 1.00 | 0.15 | ||
| A/G | 90 (50.3%) | 45 (40.9%) | 0.70 (0.43–1.14) | ||||
| Log-additive | – | – | – | 1.12 (0.80–1.57) | 0.51 | ||