Table 4.
Association of polymorphisms within the genes encoding Toll-like receptors (TLRs) and Triggering receptor expressed on myeloid cells-1 (TREM-1) with coronary atherosclerosis regarding the number of affected coronary arteries (after the adjustments by age and gender).
| Polymorphism | Inheritance model | Genotype | One affected coronary artery | Two or three affected coronary arteries | OR (95% CI) | P value | HWE |
|---|---|---|---|---|---|---|---|
| TLR1 gene | |||||||
| rs5743551 | Codominant | T/T | 40 (58%) | 150 (67.9%) | 1.00 | 0.16 | 0.85 |
| C/T | 28 (40.6%) | 63 (28.5%) | 0.61 (0.35–1.08) | ||||
| C/C | 1 (1.4%) | 8 (3.6%) | 2.13 (0.26–17.76) | ||||
| Dominant | T/T | 40 (58%) | 150 (67.9%) | 1.00 | 0.16 | ||
| C/T-C/C | 29 (42%) | 71 (32.1%) | 0.66 (0.38–1.17) | ||||
| Recessive | T/T-C/T | 68 (98.5%) | 213 (96.4%) | 1.00 | 0.33 | ||
| C/C | 1 (1.4%) | 8 (3.6%) | 2.54 (0.31–20.90) | ||||
| Overdominant | T/T-C/C | 41 (59.4%) | 158 (71.5%) | 1.00 | 0.077 | ||
| C/T | 28 (40.6%) | 63 (28.5%) | 0.60 (0.34–1.05) | ||||
| Log-additive | – | – | – | 0.79 (0.48–1.28) | 0.34 | ||
| rs5743611 | Codominant | C/C | 43 (62.3%) | 129 (58.1%) | 1.00 | 0.86 | 0.87 |
| C/G | 23 (33.3%) | 80 (36%) | 1.11 (0.62–1.99) | ||||
| G/G | 3 (4.3%) | 13 (5.9%) | 1.36 (0.37–5.07) | ||||
| Dominant | C/C | 43 (62.3%) | 129 (58.1%) | 1.00 | 0.65 | ||
| C/G-G/G | 26 (37.7%) | 93 (41.9%) | 1.14 (0.65–2.00) | ||||
| Recessive | C/C-C/G | 66 (95.7%) | 209 (94.1%) | 1.00 | 0.68 | ||
| G/G | 3 (4.3%) | 13 (5.9%) | 1.31 (0.36–4.80) | ||||
| Overdominant | C/C-G/G | 46 (66.7%) | 142 (64%) | 1.00 | 0.78 | ||
| C/G | 23 (33.3%) | 80 (36%) | 1.08 (0.61–1.93) | ||||
| Log-additive | – | – | – | 1.13 (0.71–1.81) | 0.59 | ||
| TLR2 gene | |||||||
| rs5743708 | – | G/G | 62 (89.9%) | 206 (92.8%) | 1.00 | 0.46 | 0.99 |
| A/G | 7 (10.1%) | 16 (7.2%) | 0.69 (0.27–1.79) | ||||
| rs3804099 | Codominant | T/T | 27 (39.1%) | 96 (43.2%) | 1.00 | 0.46 | 0.99 |
| C/T | 32 (46.4%) | 86 (38.7%) | 0.73 (0.40–1.33) | ||||
| C/C | 10 (14.5%) | 40 (18%) | 1.11 (0.49–2.54) | ||||
| Dominant | T/T | 27 (39.1%) | 96 (43.2%) | 1.00 | 0.49 | ||
| C/T-C/C | 42 (60.9%) | 126 (56.8%) | 0.82 (0.47–1.44) | ||||
| Recessive | T/T-C/T | 59 (85.5%) | 182 (82%) | 1.00 | 0.48 | ||
| C/C | 10 (14.5%) | 40 (18%) | 1.31 (0.61–2.80) | ||||
| Overdominant | T/T-C/C | 37 (53.6%) | 136 (61.3%) | 1.00 | 0.22 | ||
| C/T | 32 (46.4%) | 86 (38.7%) | 0.71 (0.41–1.23) | ||||
| Log-additive | – | – | – | 0.98 (0.67–1.42) | 0.91 | ||
| TLR4 gene | |||||||
| rs4986790 | Codominant | A/A | 62 (89.9%) | 183 (82.4%) | 1.00 | 0.14 | 0.99 |
| A/G | 7 (10.1%) | 37 (16.7%) | 2.07 (0.87–4.98) | ||||
| G/G | 0 (0%) | 2 (0.9%) | NA (0.00–NA) | ||||
| Dominant | A/A | 62 (89.9%) | 183 (82.4%) | 1.00 | 0.064 | ||
| A/G-G/G | 7 (10.1%) | 39 (17.6%) | 2.17 (0.91–5.17) | ||||
| Recessive | A/A-A/G | 69 (100%) | 220 (99.1%) | 1.00 | 0.34 | ||
| G/G | 0 (0%) | 2 (0.9%) | NA (0.00–NA) | ||||
| Overdominant | A/A-G/G | 62 (89.9%) | 185 (83.3%) | 1.00 | 0.086 | ||
| A/G | 7 (10.1%) | 37 (16.7%) | 2.06 (0.86–4.95) | ||||
| Log-additive | – | – | – | 2.17 (0.93–5.08) | 0.055 | ||
| rs4986791 | Codominant | C/C | 61 (88.4%) | 182 (82%) | 1.00 | 0.21 | 0.99 |
| C/T | 8 (11.6%) | 38 (17.1%) | 1.84 (0.80–4.22) | ||||
| T/T | 0 (0%) | 2 (0.9%) | NA (0.00–NA) | ||||
| Dominant | C/C | 61 (88.4%) | 182 (82%) | 1.00 | 0.11 | ||
| C/T-T/T | 8 (11.6%) | 40 (18%) | 1.92 (0.84–4.38) | ||||
| Recessive | C/C-C/T | 69 (100%) | 220 (99.1%) | 1.00 | 0.34 | ||
| T/T | 0 (0%) | 2 (0.9%) | NA (0.00–NA) | ||||
| Overdominant | C/C-T/T | 61 (88.4%) | 184 (82.9%) | 1.00 | 0.14 | ||
| C/T | 8 (11.6%) | 38 (17.1%) | 1.83 (0.79–4.20) | ||||
| Log-additive | – | – | – | 1.93 (0.86–4.33) | 0.091 | ||
| TLR6 gene | |||||||
| rs3775073 | Codominant | T/T | 24 (34.8%) | 67 (30.2%) | 1.00 | 0.8 | 0.91 |
| T/C | 31 (44.9%) | 111 (50%) | 1.24 (0.66–2.30) | ||||
| C/C | 14 (20.3%) | 44 (19.8%) | 1.13 (0.52–2.43) | ||||
| Dominant | T/T | 24 (34.8%) | 67 (30.2%) | 1.00 | 0.54 | ||
| T/C-C/C | 45 (65.2%) | 155 (69.8%) | 1.20 (0.67–2.14) | ||||
| Recessive | T/T-T/C | 55 (79.7%) | 178 (80.2%) | 1.00 | 0.98 | ||
| C/C | 14 (20.3%) | 44 (19.8%) | 0.99 (0.50–1.96) | ||||
| Overdominant | T/T-C/C | 38 (55.1%) | 111 (50%) | 1.00 | 0.55 | ||
| T/C | 31 (44.9%) | 111 (50%) | 1.18 (0.68–2.04) | ||||
| Log-additive | – | – | – | 1.08 (0.73–1.59) | 0.69 | ||
| rs5743810 | Codominant | G/G | 31 (44.9%) | 92 (41.4%) | 1.00 | 0.52 | 0.52 |
| A/G | 31 (44.9%) | 97 (43.7%) | 1.01 (0.56–1.80) | ||||
| A/A | 7 (10.1%) | 33 (14.9%) | 1.64 (0.65–4.12) | ||||
| Dominant | G/G | 31 (44.9%) | 92 (41.4%) | 1.00 | 0.68 | ||
| A/G-A/A | 38 (55.1%) | 130 (58.6%) | 1.12 (0.65–1.95) | ||||
| Recessive | G/G-A/G | 62 (89.9%) | 189 (85.1%) | 1.00 | 0.25 | ||
| A/A | 7 (10.1%) | 33 (14.9%) | 1.63 (0.68–3.92) | ||||
| Overdominant | G/G-A/A | 38 (55.1%) | 125 (56.3%) | 1.00 | 0.72 | ||
| A/G | 31 (44.9%) | 97 (43.7%) | 0.90 (0.52–1.57) | ||||
| Log-additive | – | – | – | 1.19 (0.80–1.77) | 0.39 | ||
| TREM-1 gene | |||||||
| rs2234246 | Codominant | C/C | 20 (29%) | 90 (40.5%) | 1.00 | 0.23 | 0.14 |
| C/T | 36 (52.2%) | 92 (41.4%) | 0.58 (0.31–1.09) | ||||
| T/T | 13 (18.8%) | 40 (18%) | 0.68 (0.31–1.52) | ||||
| Dominant | C/C | 20 (29%) | 90 (40.5%) | 1.00 | 0.096 | ||
| C/T-T/T | 49 (71%) | 132 (59.5%) | 0.61 (0.34–1.10) | ||||
| Recessive | C/C-C/T | 56 (81.2%) | 182 (82%) | 1.00 | 0.85 | ||
| T/T | 13 (18.8%) | 40 (18%) | 0.94 (0.46–1.89) | ||||
| Overdominant | C/C-T/T | 33 (47.8%) | 130 (58.6%) | 1.00 | 0.15 | ||
| C/T | 36 (52.2%) | 92 (41.4%) | 0.67 (0.38–1.15) | ||||
| Log-additive | – | – | – | 0.79 (0.54–1.16) | 0.23 | ||
| rs4711668 | Codominant | C/C | 24 (34.8%) | 75 (33.9%) | 1.00 | 0.093 | 0.99 |
| T/C | 34 (49.3%) | 84 (38%) | 0.86 (0.46–1.60) | ||||
| T/T | 11 (15.9%) | 62 (28.1%) | 1.92 (0.86–4.26) | ||||
| Dominant | C/C | 24 (34.8%) | 75 (33.9%) | 1.00 | 0.7 | ||
| T/C-T/T | 45 (65.2%) | 146 (66.1%) | 1.12 (0.63–2.00) | ||||
| Recessive | C/C-T/C | 58 (84.1%) | 159 (72%) | 1.00 | 0.034 | ||
| T/T | 11 (15.9%) | 62 (28.1%) | 2.09 (1.02–4.27) | ||||
| Overdominant | C/C-T/T | 35 (50.7%) | 137 (62%) | 1.00 | 0.15 | ||
| T/C | 34 (49.3%) | 84 (38%) | 0.67 (0.38–1.16) | ||||
| Log-additive | – | – | – | 1.30 (0.90–1.88) | 0.16 | ||
| rs3804277 | Codominant | C/C | 24 (34.8%) | 91 (41%) | 1.00 | 0.63 | 0.11 |
| C/T | 33 (47.8%) | 92 (41.4%) | 0.74 (0.41–1.36) | ||||
| T/T | 12 (17.4%) | 39 (17.6%) | 0.85 (0.38–1.88) | ||||
| Dominant | C/C | 24 (34.8%) | 91 (41%) | 1.00 | 0.37 | ||
| C/T-T/T | 45 (65.2%) | 131 (59%) | 0.77 (0.44–1.36) | ||||
| Recessive | C/C-C/T | 57 (82.6%) | 183 (82.4%) | 1.00 | 0.99 | ||
| T/T | 12 (17.4%) | 39 (17.6%) | 1.00 (0.48–2.05) | ||||
| Overdominant | C/C-T/T | 36 (52.2%) | 130 (58.6%) | 1.00 | 0.38 | ||
| C/T | 33 (47.8%) | 92 (41.4%) | 0.78 (0.45–1.36) | ||||
| Log-additive | – | – | – | 0.89 (0.61–1.30) | 0.54 | ||
| rs2234237 | Codominant | T/T | 48 (69.6%) | 176 (79.3%) | 1.00 | 0.22 | 0.41 |
| A/T | 18 (26.1%) | 40 (18%) | 0.61 (0.32–1.16) | ||||
| A/A | 3 (4.3%) | 6 (2.7%) | 0.44 (0.10–1.87) | ||||
| Dominant | T/T | 48 (69.6%) | 176 (79.3%) | 1.00 | 0.09 | ||
| A/T-A/A | 21 (30.4%) | 46 (20.7%) | 0.58 (0.31–1.08) | ||||
| Recessive | T/T-A/T | 66 (95.7%) | 216 (97.3%) | 1.00 | 0.35 | ||
| A/A | 3 (4.3%) | 6 (2.7%) | 0.49 (0.12–2.07) | ||||
| Overdominant | T/T-A/A | 51 (73.9%) | 182 (82%) | 1.00 | 0.17 | ||
| A/T | 18 (26.1%) | 40 (18%) | 0.63 (0.33–1.20) | ||||
| Log-additive | – | – | – | 0.63 (0.38–1.05) | 0.083 | ||
| rs6910730 | Codominant | A/A | 49 (71%) | 178 (80.2%) | 1.00 | 0.23 | 0.67 |
| A/G | 18 (26.1%) | 38 (17.1%) | 0.56 (0.29–1.08) | ||||
| G/G | 2 (2.9%) | 6 (2.7%) | 0.68 (0.13–3.54) | ||||
| Dominant | A/A | 49 (71%) | 178 (80.2%) | 1.00 | 0.087 | ||
| A/G-G/G | 20 (29%) | 44 (19.8%) | 0.57 (0.31–1.07) | ||||
| Recessive | A/A-A/G | 67 (97.1%) | 216 (97.3%) | 1.00 | 0.76 | ||
| G/G | 2 (2.9%) | 6 (2.7%) | 0.77 (0.15–3.99) | ||||
| Overdominant | A/A-G/G | 51 (73.9%) | 184 (82.9%) | 1.00 | 0.096 | ||
| A/G | 18 (26.1%) | 38 (17.1%) | 0.57 (0.30–1.09) | ||||
| Log-additive | – | – | – | 0.66 (0.39–1.11) | 0.12 | ||
| rs1817537 | Codominant | C/C | 24 (34.8%) | 91 (41%) | 1.00 | 0.63 | 0.11 |
| C/G | 33 (47.8%) | 92 (41.4%) | 0.74 (0.41–1.36) | ||||
| G/G | 12 (17.4%) | 39 (17.6%) | 0.85 (0.38–1.88) | ||||
| Dominant | C/C | 24 (34.8%) | 91 (41%) | 1.00 | 0.37 | ||
| C/G-G/G | 45 (65.2%) | 131 (59%) | 0.77 (0.44–1.36) | ||||
| Recessive | C/C-C/G | 57 (82.6%) | 183 (82.4%) | 1.00 | 0.99 | ||
| G/G | 12 (17.4%) | 39 (17.6%) | 1.00 (0.48–2.05) | ||||
| Overdominant | C/C-G/G | 36 (52.2%) | 130 (58.6%) | 1.00 | 0.38 | ||
| C/G | 33 (47.8%) | 92 (41.4%) | 0.78 (0.45–1.36) | ||||
| Log-additive | – | – | – | 0.89 (0.61–1.30) | 0.54 | ||
| rs9471535 | Codominant | T/T | 48 (69.6%) | 173 (78.6%) | 1.00 | 0.26 | 0.41 |
| C/T | 18 (26.1%) | 41 (18.6%) | 0.63 (0.33–1.21) | ||||
| C/C | 3 (4.3%) | 6 (2.7%) | 0.45 (0.11–1.90) | ||||
| Dominant | T/T | 48 (69.6%) | 173 (78.6%) | 1.00 | 0.11 | ||
| C/T-C/C | 21 (30.4%) | 47 (21.4%) | 0.60 (0.33–1.12) | ||||
| Recessive | T/T-C/T | 66 (95.7%) | 214 (97.3%) | 1.00 | 0.36 | ||
| C/C | 3 (4.3%) | 6 (2.7%) | 0.50 (0.12–2.09) | ||||
| Overdominant | T/T-C/C | 51 (73.9%) | 179 (81.4%) | 1.00 | 0.2 | ||
| C/T | 18 (26.1%) | 41 (18.6%) | 0.65 (0.34–1.24) | ||||
| Log-additive | – | – | – | 0.65 (0.39–1.08) | 0.1 | ||
| rs7768162 | Codominant | G/G | 25 (36.2%) | 79 (35.9%) | 1.00 | 0.21 | 0.63 |
| A/G | 37 (53.6%) | 98 (44.5%) | 0.93 (0.51–1.69) | ||||
| A/A | 7 (10.1%) | 43 (19.6%) | 1.97 (0.78–4.96) | ||||
| Dominant | G/G | 25 (36.2%) | 79 (35.9%) | 1.00 | 0.74 | ||
| A/G-A/A | 44 (63.8%) | 141 (64.1%) | 1.10 (0.62–1.95) | ||||
| Recessive | G/G-A/G | 62 (89.9%) | 177 (80.5%) | 1.00 | 0.079 | ||
| A/A | 7 (10.1%) | 43 (19.6%) | 2.06 (0.88–4.85) | ||||
| Overdominant | G/G-A/A | 32 (46.4%) | 122 (55.5%) | 1.00 | 0.34 | ||
| A/G | 37 (53.6%) | 98 (44.5%) | 0.76 (0.44–1.33) | ||||
| Log-additive | – | – | – | 1.26 (0.84–1.88) | 0.26 | ||