Table 6.
Association of polymorphisms within the genes encoding Toll-like receptors (TLRs) and Triggering receptor expressed on myeloid cells-1 (TREM-1) with hemodynamically significant (≥ 50%) stenosis of extracranial or/and lower extremity arteries (after the adjustments by age and gender).
| Polymorphism | Inheritance model | Genotype | No stenosis or < 50% stenosis | ≥ 50% stenosis | OR (95% CI) | P value | HWE |
|---|---|---|---|---|---|---|---|
| TLR1 gene | |||||||
| rs5743551 | Codominant | T/T | 136 (65.4%) | 54 (65.8%) | 1.00 | 0.43 | 0.85 |
| C/T | 64 (30.8%) | 27 (32.9%) | 1.08 (0.62–1.89) | ||||
| C/C | 8 (3.8%) | 1 (1.2%) | 0.32 (0.04–2.61) | ||||
| Dominant | T/T | 136 (65.4%) | 54 (65.8%) | 1.00 | 0.99 | ||
| C/T-C/C | 72 (34.6%) | 28 (34.1%) | 1.00 (0.58–1.72) | ||||
| Recessive | T/T-C/T | 200 (96.2%) | 81 (98.8%) | 1.00 | 0.21 | ||
| C/C | 8 (3.8%) | 1 (1.2%) | 0.31 (0.04–2.53) | ||||
| Overdominant | T/T-C/C | 144 (69.2%) | 55 (67.1%) | 1.00 | 0.68 | ||
| C/T | 64 (30.8%) | 27 (32.9%) | 1.13 (0.65–1.96) | ||||
| Log-additive | – | – | – | 0.91 (0.56–1.47) | 0.7 | ||
| rs5743611 | Codominant | C/C | 126 (60.6%) | 46 (55.4%) | 1.00 | 0.64 | 0.87 |
| C/G | 70 (33.6%) | 33 (39.8%) | 1.26 (0.73–2.16) | ||||
| G/G | 12 (5.8%) | 4 (4.8%) | 0.85 (0.26–2.81) | ||||
| Dominant | C/C | 126 (60.6%) | 46 (55.4%) | 1.00 | 0.49 | ||
| C/G-G/G | 82 (39.4%) | 37 (44.6%) | 1.20 (0.71–2.02) | ||||
| Recessive | C/C-C/G | 196 (94.2%) | 79 (95.2%) | 1.00 | 0.67 | ||
| G/G | 12 (5.8%) | 4 (4.8%) | 0.78 (0.24–2.51) | ||||
| Overdominant | C/C-G/G | 138 (66.3%) | 50 (60.2%) | 1.00 | 0.37 | ||
| C/G | 70 (33.6%) | 33 (39.8%) | 1.28 (0.75–2.17) | ||||
| Log-additive | – | – | – | 1.09 (0.71–1.67) | 0.69 | ||
| TLR2 gene | |||||||
| rs5743708 | – | G/G | 192 (92.3%) | 76 (91.6%) | 1.00 | 0.82 | 0.99 |
| A/G | 16 (7.7%) | 7 (8.4%) | 1.12 (0.44–2.85) | ||||
| rs3804099 | Codominant | T/T | 88 (42.3%) | 35 (42.2%) | 1.00 | 0.92 | 0.075 |
| C/T | 85 (40.9%) | 33 (39.8%) | 0.99 (0.56–1.74) | ||||
| C/C | 35 (16.8%) | 15 (18.1%) | 1.15 (0.55–2.38) | ||||
| Dominant | T/T | 88 (42.3%) | 35 (42.2%) | 1.00 | 0.91 | ||
| C/T-C/C | 120 (57.7%) | 48 (57.8%) | 1.03 (0.61–1.74) | ||||
| Recessive | T/T-C/T | 173 (83.2%) | 68 (81.9%) | 1.00 | 0.68 | ||
| C/C | 35 (16.8%) | 15 (18.1%) | 1.15 (0.59–2.27) | ||||
| Overdominant | T/T-C/C | 123 (59.1%) | 50 (60.2%) | 1.00 | 0.84 | ||
| C/T | 85 (40.9%) | 33 (39.8%) | 0.95 (0.56–1.60) | ||||
| Log-additive | – | – | – | 1.05 (0.74–1.50) | 0.77 | ||
| TLR4 gene | |||||||
| rs4986790 | Codominant | A/A | 180 (86.5%) | 65 (78.3%) | 1.00 | 0.015 | 0.99 |
| A/G | 28 (13.5%) | 16 (19.3%) | 1.70 (0.85–3.41) | ||||
| G/G | 0 (0%) | 2 (2.4%) | NA (0.00–NA) | ||||
| Dominant | A/A | 180 (86.5%) | 65 (78.3%) | 1.00 | 0.053 | ||
| A/G-G/G | 28 (13.5%) | 18 (21.7%) | 1.96 (1.00–3.84) | ||||
| Recessive | A/A-A/G | 208 (100%) | 81 (97.6%) | 1.00 | 0.012 | ||
| G/G | 0 (0%) | 2 (2.4%) | NA (0.00–NA) | ||||
| Overdominant | A/A-G/G | 180 (86.5%) | 67 (80.7%) | 1.00 | 0.16 | ||
| A/G | 28 (13.5%) | 16 (19.3%) | 1.66 (0.83–3.32) | ||||
| Log-additive | – | – | – | 2.12 (1.13–3.96) | 0.02 | ||
| rs4986791 | Codominant | C/C | 178 (85.6%) | 65 (78.3%) | 1.00 | 0.02 | 0.99 |
| C/T | 30 (14.4%) | 16 (19.3%) | 1.56 (0.78–3.09) | ||||
| T/T | 0 (0%) | 2 (2.4%) | NA (0.00–NA) | ||||
| Dominant | C/C | 178 (85.6%) | 65 (78.3%) | 1.00 | 0.088 | ||
| C/T-T/T | 30 (14.4%) | 18 (21.7%) | 1.80 (0.92–3.49) | ||||
| Recessive | C/C-C/T | 208 (100%) | 81 (97.6%) | 1.00 | 0.012 | ||
| T/T | 0 (0%) | 2 (2.4%) | NA (0.00–NA) | ||||
| Overdominant | C/C-T/T | 178 (85.6%) | 67 (80.7%) | 1.00 | 0.23 | ||
| C/T | 30 (14.4%) | 16 (19.3%) | 1.52 (0.77–3.02) | ||||
| Log-additive | – | – | – | 1.96 (1.06–3.63) | 0.036 | ||
| TLR6 gene | |||||||
| rs3775073 | Codominant | T/T | 68 (32.7%) | 23 (27.7%) | 1.00 | 0.65 | 0.91 |
| T/C | 101 (48.6%) | 41 (49.4%) | 1.15 (0.63–2.11) | ||||
| C/C | 39 (18.8%) | 19 (22.9%) | 1.41 (0.68–2.94) | ||||
| Dominant | T/T | 68 (32.7%) | 23 (27.7%) | 1.00 | 0.48 | ||
| T/C-C/C | 140 (67.3%) | 60 (72.3%) | 1.23 (0.70–2.16) | ||||
| Recessive | T/T-T/C | 169 (81.2%) | 64 (77.1%) | 1.00 | 0.42 | ||
| C/C | 39 (18.8%) | 19 (22.9%) | 1.29 (0.69–2.42) | ||||
| Overdominant | T/T-C/C | 107 (51.4%) | 42 (50.6%) | 1.00 | 0.99 | ||
| T/C | 101 (48.6%) | 41 (49.4%) | 1.00 (0.60–1.68) | ||||
| Log-additive | – | – | – | 1.19 (0.82–1.71) | 0.36 | ||
| rs5743810 | Codominant | G/G | 86 (41.4%) | 37 (44.6%) | 1.00 | 0.8 | 0.52 |
| A/G | 92 (44.2%) | 36 (43.4%) | 0.89 (0.51–1.54) | ||||
| A/A | 30 (14.4%) | 10 (12.1%) | 0.77 (0.34–1.76) | ||||
| Dominant | G/G | 86 (41.4%) | 37 (44.6%) | 1.00 | 0.56 | ||
| A/G-A/A | 122 (58.6%) | 46 (55.4%) | 0.86 (0.51–1.44) | ||||
| Recessive | G/G-A/G | 178 (85.6%) | 73 (88%) | 1.00 | 0.62 | ||
| A/A | 30 (14.4%) | 10 (12.1%) | 0.82 (0.38–1.78) | ||||
| Overdominant | G/G-A/A | 116 (55.8%) | 47 (56.6%) | 1.00 | 0.82 | ||
| A/G | 92 (44.2%) | 36 (43.4%) | 0.94 (0.56–1.58) | ||||
| Log-additive | – | – | – | 0.88 (0.61–1.28) | 0.51 | ||
| TREM-1 gene | |||||||
| rs2234246 | Codominant | C/C | 77 (37%) | 33 (39.8%) | 1.00 | 0.72 | 0.14 |
| C/T | 91 (43.8%) | 37 (44.6%) | 0.95 (0.54–1.68) | ||||
| T/T | 40 (19.2%) | 13 (15.7%) | 0.74 (0.35–1.57) | ||||
| Dominant | C/C | 77 (37%) | 33 (39.8%) | 1.00 | 0.66 | ||
| C/T-T/T | 131 (63%) | 50 (60.2%) | 0.89 (0.52–1.50) | ||||
| Recessive | C/C-C/T | 168 (80.8%) | 70 (84.3%) | 1.00 | 0.42 | ||
| T/T | 40 (19.2%) | 13 (15.7%) | 0.76 (0.38–1.51) | ||||
| Overdominant | C/C-T/T | 117 (56.2%) | 46 (55.4%) | 1.00 | 0.86 | ||
| C/T | 91 (43.8%) | 37 (44.6%) | 1.05 (0.63–1.76) | ||||
| Log-additive | – | – | – | 0.88 (0.61–1.25) | 0.47 | ||
| rs4711668 | Codominant | C/C | 72 (34.6%) | 27 (32.9%) | 1.00 | 0.83 | 0.0021 |
| T/C | 83 (39.9%) | 35 (42.7%) | 1.20 (0.66–2.19) | ||||
| T/T | 53 (25.5%) | 20 (24.4%) | 1.07 (0.54–2.12) | ||||
| Dominant | C/C | 72 (34.6%) | 27 (32.9%) | 1.00 | 0.62 | ||
| T/C-T/T | 136 (65.4%) | 55 (67.1%) | 1.15 (0.66–1.99) | ||||
| Recessive | C/C-T/C | 155 (74.5%) | 62 (75.6%) | 1.00 | 0.91 | ||
| T/T | 53 (25.5%) | 20 (24.4%) | 0.97 (0.53–1.75) | ||||
| Overdominant | C/C-T/T | 125 (60.1%) | 47 (57.3%) | 1.00 | 0.56 | ||
| T/C | 83 (39.9%) | 35 (42.7%) | 1.17 (0.69–1.97) | ||||
| Log-additive | – | – | – | 1.04 (0.74–1.46) | 0.81 | ||
| rs3804277 | Codominant | C/C | 82 (39.4%) | 33 (39.8%) | 1.00 | 0.8 | 0.11 |
| C/T | 88 (42.3%) | 37 (44.6%) | 1.04 (0.60–1.83) | ||||
| T/T | 38 (18.3%) | 13 (15.7%) | 0.82 (0.38–1.74) | ||||
| Dominant | C/C | 82 (39.4%) | 33 (39.8%) | 1.00 | 0.92 | ||
| C/T-T/T | 126 (60.6%) | 50 (60.2%) | 0.97 (0.58–1.65) | ||||
| Recessive | C/C-C/T | 170 (81.7%) | 70 (84.3%) | 1.00 | 0.52 | ||
| T/T | 38 (18.3%) | 13 (15.7%) | 0.80 (0.40–1.60) | ||||
| Overdominant | C/C-T/T | 120 (57.7%) | 46 (55.4%) | 1.00 | 0.69 | ||
| C/T | 88 (42.3%) | 37 (44.6%) | 1.11 (0.66–1.86) | ||||
| Log-additive | – | – | – | 0.93 (0.65–1.33) | 0.69 | ||
| rs2234237 | Codominant | T/T | 161 (77.4%) | 63 (75.9%) | 1.00 | 0.79 | 0.064 |
| A/T | 40 (19.2%) | 18 (21.7%) | 1.13 (0.60–2.14) | ||||
| A/A | 7 (3.4%) | 2 (2.4%) | 0.66 (0.13–3.29) | ||||
| Dominant | T/T | 161 (77.4%) | 63 (75.9%) | 1.00 | 0.85 | ||
| A/T-A/A | 47 (22.6%) | 20 (24.1%) | 1.06 (0.58–1.94) | ||||
| Recessive | T/T-A/T | 201 (96.6%) | 81 (97.6%) | 1.00 | 0.57 | ||
| A/A | 7 (3.4%) | 2 (2.4%) | 0.64 (0.13–3.19) | ||||
| Overdominant | T/T-A/A | 168 (80.8%) | 65 (78.3%) | 1.00 | 0.66 | ||
| A/T | 40 (19.2%) | 18 (21.7%) | 1.15 (0.61–2.17) | ||||
| Log-additive | – | – | – | 0.99 (0.60–1.64) | 0.97 | ||
| rs6910730 | Codominant | A/A | 163 (78.4%) | 64 (77.1%) | 1.00 | 0.93 | 0.059 |
| A/G | 39 (18.8%) | 17 (20.5%) | 1.07 (0.56–2.04) | ||||
| G/G | 6 (2.9%) | 2 (2.4%) | 0.78 (0.15–4.02) | ||||
| Dominant | A/A | 163 (78.4%) | 64 (77.1%) | 1.00 | 0.92 | ||
| A/G-G/G | 45 (21.6%) | 19 (22.9%) | 1.03 (0.56–1.91) | ||||
| Recessive | A/A-A/G | 202 (97.1%) | 81 (97.6%) | 1.00 | 0.75 | ||
| G/G | 6 (2.9%) | 2 (2.4%) | 0.77 (0.15–3.95) | ||||
| Overdominant | A/A-G/G | 169 (81.2%) | 66 (79.5%) | 1.00 | 0.81 | ||
| A/G | 39 (18.8%) | 17 (20.5%) | 1.08 (0.57–2.06) | ||||
| Log-additive | – | – | – | 0.99 (0.59–1.67) | 0.98 | ||
| rs1817537 | Codominant | C/C | 82 (39.4%) | 33 (39.8%) | 1.00 | 0.8 | 0.11 |
| C/G | 88 (42.3%) | 37 (44.6%) | 1.04 (0.60–1.83) | ||||
| G/G | 38 (18.3%) | 13 (15.7%) | 0.82 (0.38–1.74) | ||||
| Dominant | C/C | 82 (39.4%) | 33 (39.8%) | 1.00 | 0.92 | ||
| C/G-G/G | 126 (60.6%) | 50 (60.2%) | 0.97 (0.58–1.65) | ||||
| Recessive | C/C-C/G | 170 (81.7%) | 70 (84.3%) | 1.00 | 0.52 | ||
| G/G | 38 (18.3%) | 13 (15.7%) | 0.80 (0.40–1.60) | ||||
| Overdominant | C/C-G/G | 120 (57.7%) | 46 (55.4%) | 1.00 | 0.69 | ||
| C/G | 88 (42.3%) | 37 (44.6%) | 1.11 (0.66–1.86) | ||||
| Log-additive | – | – | – | 0.93 (0.65–1.33) | 0.69 | ||
| rs9471535 | Codominant | T/T | 159 (76.8%) | 62 (75.6%) | 1.00 | 0.81 | 0.068 |
| C/T | 41 (19.8%) | 18 (21.9%) | 1.10 (0.59–2.08) | ||||
| C/C | 7 (3.4%) | 2 (2.4%) | 0.65 (0.13–3.26) | ||||
| Dominant | T/T | 159 (76.8%) | 62 (75.6%) | 1.00 | 0.92 | ||
| C/T-C/C | 48 (23.2%) | 20 (24.4%) | 1.03 (0.56–1.89) | ||||
| Recessive | T/T-C/T | 200 (96.6%) | 80 (97.6%) | 1.00 | 0.57 | ||
| C/C | 7 (3.4%) | 2 (2.4%) | 0.64 (0.13–3.17) | ||||
| Overdominant | T/T-C/C | 166 (80.2%) | 64 (78%) | 1.00 | 0.72 | ||
| C/T | 41 (19.8%) | 18 (21.9%) | 1.12 (0.60–2.11) | ||||
| Log-additive | – | – | – | 0.97 (0.59–1.62) | 0.92 | ||
| rs7768162 | Codominant | G/G | 75 (36.2%) | 29 (35.4%) | 1.00 | 0.75 | 0.63 |
| A/G | 95 (45.9%) | 40 (48.8%) | 1.18 (0.76–2.11) | ||||
| A/A | 37 (17.9%) | 13 (15.8%) | 0.92 (0.43–1.99) | ||||
| Dominant | G/G | 75 (36.2%) | 29 (35.4%) | 1.00 | 0.71 | ||
| A/G-A/A | 132 (63.8%) | 53 (64.6%) | 1.11 (0.64–1.90) | ||||
| Recessive | G/G-A/G | 170 (82.1%) | 69 (84.2%) | 1.00 | 0.62 | ||
| A/A | 37 (17.9%) | 13 (15.8%) | 0.84 (0.42–1.69) | ||||
| Overdominant | G/G-A/A | 112 (54.1%) | 42 (51.2%) | 1.00 | 0.47 | ||
| A/G | 95 (45.9%) | 40 (48.8%) | 1.22 (0.72–2.05) | ||||
| Log-additive | – | – | – | 1.00 (0.69–1.44) | 0.99 | ||