Figure 2.

UNC‐105‐induced protein degradation is not suppressed by known suppressors of protein degradation or neurodegeneration in Caenorhabditis elegans. Synchronized young adults were used (t = 0 h), and all experiments repeated at least three times. Representative stains for β‐galactosidase at t = 72 h post‐adulthood; scale bar represents 100 µm. (A) Untreated unc‐105 mutants. (B) RNAi against known suppressors of unc‐105 growth or movement defect. (C) RNAi or drugs targeting known components of calpain,13 proteasome,4, 6 or autophagic8, 10 muscle protein degradation in C. elegans. (D) RNAi against known suppressors of MEC‐4 degenerin‐induced neuronal degeneration.