Figure 5.

Cachexia phenotype of Lewis lung carcinoma‐bearing (LLC) transgenic mice expressing the dominant‐negative transient receptor potential vanilloid 2 (TRPV2). Time‐dependent changes in body weight (A) and food intake (B) in phosphate buffered saline (PBS) (control) or LLC‐injected mice. LLC cells (5 × 10⁶ cells) or PBS (control) were subcutaneously injected into transgenic mice expressing dominant‐negative TRPV2 (DN‐Tg) (n = 4). The data represent the mean ± standard error. *P < 0.05, **P < 0.01, and *** P < 0.001 compared with control mice. Body weights (C), weights of gastrocnemius (D) and soleus muscles (E), grip force (F), or locomotor activity (G) in control (PBS‐injected) or LLC‐injected transgenic mice expressing dominant‐negative TRPV2 (DN‐Tg) at 24 days post‐injection. In (A), tumour‐removed body weight is represented for LLC‐injected DN‐Tg mice.