Table 3. Cardiac function.
| Parameter | Kcc3−/− | Kcc3+/+ | p |
|---|---|---|---|
| A) Cardiac weight | (n = 29) | (n = 32) | |
| ‒ Absolute (mg) | 149.1 ± 2.7 | 141.1 ± 2.9 | 0.0491 * |
| ‒ Relative to body weight (%) | 0.510 ± 0.007 | 0.391 ± 0.010 | < 10−13 * |
| B) Echocardiographic parameters | (n = 8) | (n = 8) | |
| ‒ End-diastolic diameter (mm) | 4.18 ± 0.05 | 3.85 ± 0.05 | 0.0182 † |
| ‒ End-systolic diameter (mm) | 2.32 ± 0.10 | 2.24 ± 0.07 | 0.6988 |
| ‒ Ejection fraction (%) | 69 ± 2 | 66 ± 2 | 0.5635 |
| ‒ LV weight (mg) | 136 ±5 | 117 ± 6 | 0.0520 |
| ‒ LV weight relative to tibial length (mg mm-1) | 6.32 ± 0.25 | 5.24 ± 0.30 | 0.0240 † |
| ‒ LV weight relative to body weight (%) | 0.544 ± 0.025 | 0.408 ± 0.026 | 0.0054 † |
| ‒ Heart rate (min-1) | 386 ± 17 | 423 ± 16 | 0.0831 |
| ‒ Stroke volume (μL) | 61 ± 3 | 60 ± 4 | 0.9657 |
| ‒ Cardiac output (mL min-1) | 24 ± 1 | 25 ± 1 | 0.3184 |
| C) Parameters used for normalization | (n = 8) | (n = 8) | |
| ‒ Body weight (g) | 25.2 ± 0.8 | 28.8 ± 0.7 | 0.0054 † |
| ‒ Tibial length (mm) | 21.61 ± 0.09 | 22.30 ± 0.14 | 0.0113 † |
Data are expressed as means ± SEM. Hearts weighed were freed of blood vessels and pericardial fat. The number of mice tested among several experiments is indicated between parentheses.
* and † indicate that values in a row are significantly different statistically between each other based on Student t and Wilcoxon rank-sum tests, respectively. LV, left ventricle.