Table 4. Renal function.
| Trait | Kcc3−/− | Kcc3+/+ | p |
|---|---|---|---|
| A) Standard serum or blood measurements | |||
| ‒ Creatinine (μmol L-1) | 13.00 ± 1.09 (7) | 11.25 ± 1.46 (8) | 0.5992 |
| ‒ Urea (mmol L-1) | 10.77 ± 0.78 (7) | 10.46 ± 0.38 (8) | 0.7716 |
| ‒ Na+ (mmol L-1) | 150.3 ± 0.6 (7) | 150.5 ± 0.5 (8) | 0.5022 |
| ‒ CO2 (mmol L-1) | 14.0 ± 1.2 (7) | 15.0 ± 1.2 (8) | 0.2599 |
| ‒ Hematocrit (%) | 37.2 ± 0.5 (7) | 38.7 ± 1.0 (6) | 0.2246 |
| B) Water balance and food intake | |||
| ‒ Daily water intake (mL) | 4.0 ± 0.1 (11) | 3.0 ± 0.3 (9) | 0.0133 † |
| ‒ Hourly diuresis (μL h-1) | 50.2 ± 3.2 (11) | 31.4 ± 3.6 (9) | 0.0014 † |
| ‒ Urine osmolality (osmol kg-1) | 1.99 ± 0.11 (5) | 1.99 ± 0.15 (5) | 1.000 |
| C) Urine measurements | |||
| ‒ Na+/creatinine | 34.3 ± 3.0 (7) | 34.2 ± 1.8 (8) | 0.955 |
| ‒ Creatinine (μmol L-1) | 3.07 ± 0.12 (7) | 4.78 ± 0.25 (8) | < 0.001 † |
| ‒ Specific gravity | 1.041 ± 0.002 (7) | 1.060 ± 0.003 (7) | 0.002 † |
Studies were carried out under a regular diet. Data are expressed as means ± SEM. The number of mice tested among several experiments is indicated between parentheses.
† indicates that values in a row are significantly different statistically between each other based on a Wilcoxon rank-sum test.