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. 2016 May 12;6:25969. doi: 10.1038/srep25969

Figure 2. Sex differences in hippocampal IGF-I responses to exercise.

Figure 2

(A) In female mice, exercise increased hippocampal levels of IGF-I. However, female mice with low serum IGF-I levels (LID) showed reduced hippocampal IGF-I after exercise (n = 10 per group; *p < 0.05). (B) Exercise reduced IGF-I mRNA in wild type female mice (n = 10 per group; **p < 0.01 vs sedentary females). (C) While female mice have higher liver IGF-I mRNA levels than males, exercise slightly increased them in both sexes (n = 8 per group; **p < 0.01 vs sedentary males). (D) Exercise did not modify similar basal serum levels of IGF-I in male or female mice (n = 10 per group).