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. 2016 May 12;6:25969. doi: 10.1038/srep25969

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(A) In ovariectomized female mice exercise did not increase IGF-I levels in hippocampus (n = 8). (B) Similarly, exercise did not modify hippocampal IGF-I mRNA levels (n = 8 per group). (C,D) Levels of hippocampal IGF-I (C), but not of its mRNA (D) vary along the estrous cycle (n = 6 per group; *p < 0.05 vs proestrus).