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. 2016 May 12;6:25969. doi: 10.1038/srep25969

Figure 4. Estradiol stimulates uptake of IGF-I by brain endothelial cells.

Figure 4

(A) Cultured brain endothelial cells accumulate significantly more IGF-I after treatment with 10−10M estradiol (E2). Representative blot is shown (*p < 0.05 vs control; n = 8 per group). (B) The effects of E2 were mediated by α E2 receptors as only the α inhibitor MPP blocked E2 actions. Representative blots are shown (*p < 0.05; n = 8). (C) Levels of IGF-I receptor (green) at the cell membrane of endothelial cells are markedly increased three hours after addition of 10−10M E2.