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. 2016 May 12;6:25969. doi: 10.1038/srep25969

Figure 6. Estradiol and IGF-I mediate actions of exercise on female mood.

Figure 6

(A) Exercise modulates resilience to stress as measured in the tail suspension test in an estrogen- and serum IGF-I-dependent manner. Administration of the estrogen receptor α antagonist MPP during exercise resulted in significantly attenuated mobility. DMSO group is the vehicle group of the MPP treatment. Similarly, female mice with low serum IGF-I levels (LID mice) did not show improved resilience to stress after exercise (*p < 0.05; n = 5–10 per group). (B) Exercised LID female mice or ovariectomized wild type female mice did not show increased motor activity after vestibular stimulation (***p < 0.001 vs sedentary; n = 10 each group). Both groups of animals showed reduced basal motor activity.