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. 2016 May 12;6:26077. doi: 10.1038/srep26077

Figure 2. In vivo antibacterial activity of SET-M33L and SET-M33L-PEG peptides in lung infection.

Figure 2

(A) Survival of neutropenic BALB/c mice after peptide treatment. All animals were injected i.t. with a lethal amount of P. aeruginosa PAO1. One group of animals was treated i.v. with 5 mg/Kg SET-M33L and one group with 5 mg/Kg SET-M33L-PEG, 1 and 16 hours post-infection. The control group (CTR) only received vehicle. The groups are indicated as described in the internal legend. Percentage survival (y-axis) is plotted as a function of time (x-axis); p < 0.05. (B) Scatter plots representing the CFUs/lung (y-axis) in treated and untreated non-neutropenic mice (each circle corresponds to one mice). All animals were injected i.t. with P. aeruginosa PAO1. One group was treated i.t. with a single 5 mg/Kg dose of SET-M33L (white circles). The control group only received vehicle (black circles). The horizontal lines represent the median and the difference between medians is indicated as a percentage. p = 0.05. There were 10 mice/group.