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. 2016 May 12;6:25741. doi: 10.1038/srep25741

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Copyright © 2016, Macmillan Publishers Limited

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(a) Immunization of N-LPETGGGS-AD-4-C VLPs significantly improved the specific IgG response compared to that of GGGS-AD-4. Anti–GGGS-AD-4 antibodies were faster and stronger when induced by N-LPETGGGS-AD-4-C VLPs than when induced by GGGS-AD-4. Blood samples before antigens injection (named 0), first time injection (1st), second and third time booster (2nd and 3rd) were analyzed by ELISA. (b) Anti-GGGS-AD-4 IgG response was 100 fold increased after coupling GGGS-AD-4 to N-LPETGG-C VLP scaffold (**P < 0.001, by two-tailed student’s t-test).