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. 2016 May 12;6:25741. doi: 10.1038/srep25741

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(a) All of the HBc-based VLPs induced an anti–N-LPETGG-C VLP IgG response with a similar level. (b–c) HBc-SP55/70 and N-LPETGGG-SP55/70-C elicited similar strong specific IgG response. (d) Injection of EV71 epitope-based HBc VLPs triggered neutralizing antibodies. Sortagged VLPs performed as well as genetically fused VLPs in neutralizing EV71 entry. (e) Anti-HBc-SP70 and anti-N-LPETGGG-SP70-C serums notably protected 7-day-old ICR mice from EV71 lethal challenge (*P < 0.05, by Log-rank (Mantel-Cox) test).