Table 3. Regulatory relationship of LIF and NEK7.

Molecule	Family	Regulates	Regulated by
LIF	Cytokine	STAT3, SOCS3, POMC, Erk1/2, IL6ST, STAT1, LIFR, SOCS1, IL-6*, FGF5, FOS, Alp, T, KDR, POU5F1	lipopolysaccharide, TNF, IL-1β, progesterone, TGFB1, IL-2, Il-1, dexamethasone, LPP, MAPK8, Lethal toxin, TP53, AGT, phorbol myristate acetate, Tgf beta
NEK7	Kinase	EDN1, RGCC, LMO4, IL-12A*, U90926, ACPP, ISG15, PTGS2, CXCL10*	TLR4, PLK, triamcinolone acetonide

* pro-inflammatory cytokines and chemokines