Table 3.
Multivariate association between the 3 most contributing SSM modes of the proximal femur and SNPs previously reported to be associated with hip osteoarthritis or hip morphologya
| SNP/chromosome | P | Sex subset | SSM modes | Minor allele | MAF | |
|---|---|---|---|---|---|---|
| Before adjustment for covariates | ||||||
| rs6976/3 | 0.00149 | Mixed | 5, 7, 10 | T | 0.40 | |
| rs5009270/7 | 0.00039 | Mixed | 3, 4, 9 | A | 0.33 | |
| rs4836732/9 | 0.00044 | Female | 5, 8, 12 | T | 0.48 | |
| rs1516893/9 | 0.00237 | Mixed | 7, 10, 11 | A | 0.12 | |
| rs12901499/15 | 0.00158 | Mixed | 6, 7, 9 | A | 0.44 | |
| After adjustment for age and BMI | ||||||
| rs6976/3 | 0.00555 | Mixed | 5, 7, 10 | T | 0.40 | |
| rs5009270/7 | 0.00040 | Mixed | 3, 4, 9 | A | 0.33 | |
| rs4836732/9 | 0.00347 | Female | 5, 8, 12 | T | 0.48 | |
| rs1516893/9 | 0.00363 | Mixed | 7, 10, 11 | A | 0.12 | |
| rs12901499/15 | 0.00219 | Mixed | 6, 7, 9 | A | 0.44 | |
a
The expected level for significance after Bonferroni correction was a P value of less than 0.001. All results were obtained following an additive genetic model. SSM = statistical shape model; SNP = single‐nucleotide polymorphism; MAF = minor allele frequency; BMI = body mass index.