Figure 2.

Power of H2BK20ac to predict active enhancers in complex tissues in vivo. (A) Sensitivity in detecting active enhancers in embryonic day 11.5 (e11.5) mouse forebrain (downloaded from VISTA Enhancer Browser) (Visel et al. 2007) as a function of number of peaks called. (B) Sensitivity versus false-positive rate (receiver-operator characteristic). The positive set comprised e11.5 forebrain enhancers, and the negative set comprised those that were tested but did not show activity in neural tissues at e11.5. (C) UCSC Genome Browser snapshots of three forebrain enhancers (from VISTA browser, highlighted in yellow) marked by H2BK20ac but not H3K27ac.